»
Antibodies
»
anti-Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2 (ACE2) (N-Term) an...
Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2 (ACE2) (N-Term) antibody
| Antigen |
|
| Synonyms |
ACEH, DKFZp434A014, 2010305L05Rik, ACE2, zgc:92514, MGC127593, DKFZp469K2021, Ace2 |
|
Epitope
|
|
| Clonality |
Polyclonal |
|
Host
|
|
|
Reactivity
|
|
|
Application
|
 Alternatives Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|
| Catalog no. |
ABIN499193 |
| Quantity |
0.1 mg |
| Price |
320.00 $ Plus shipping costs $35.00
|
| Shipping to |
|
| Availability |
Ships within 7 to 10 Business Days |
|
Characteristics
|
Synonyms: Angiotensin-converting enzyme 2, ACE-related carboxypeptidase, Angiotensin-convertingenzyme homolog
|
|
Alternative name
|
ACE2
|
|
Gene ID
|
59272
|
|
Swiss-Prot
|
Q9BYF1
|
|
Immunogen
|
Human ACE2 (N-Terminus) Peptide (ABIN499192)
|
|
Cross-Reactivity
|
Human
|
|
Isotype
|
IgG (Matching secondary antibodies)
|
|
Description
|
Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, andmyocardial physiology (1-2). In contrast to its homolog ACE, ACE2 expression is restrictedto heart, kidney, and testis. Recently. ACE2 has also been shown to be a functionalreceptor of the SARS coronavirus (3). The normal function of ACE2 is to convert the inactivevasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlikeACE, which converts AngI to AngII. While the role of these vasoactive peptides is not wellunderstood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiaccontractility, indicating its importance in regulating heart function (4).
|
|
Specificity
|
ACE2 antibody was raised against a synthetic peptide corresponding to amino acids nearthe N-terminus of human ACE2. Anti-ACE2 has no cross response to ACE1. Species: Human. Others not tested. Add. Information: Blocking peptide available: blocking peptide (ABIN499192)
|
|
Application Notes
|
ELISA. Western Blot: ACE2 antibody can be used for the detection of ACE2 at 0.5 to 2 μg/ml. A 90kDa band can be detected. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
|
|
Purification
|
Aff - Purified
|
|
Buffer
|
PBS containing 0.02% sodium azide.
|
|
Storage
|
Store the antibody undiluted at 2-8°C. Shelf life: one year from despatch.
|
|
Research Area
|
Metabolism, Enzymes, Serum/Plasma Proteins
|
|
Restrictions
|
For Research Use only
|
Alternatives for antigen "Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2 (ACE2)", type "Antibodies"
|
Hosts
|
Rabbit (57), Mouse (1)
|
|
Reactivities
|
Human (57), Mouse (Murine) (24), Rat (Rattus) (20), Dog (Canine) (16), Pig (Porcine) (16), Sheep (Ovine) (15), Cow (Bovine) (1), Horse (Equine) (1)
|
|
Applications
|
Western Blotting (WB) (40), Flow Cytometry (FACS) (20), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (20), Immunofluorescence (IF) (18), ELISA (13), Enzyme Immunoassay (EIA) (12), Immunohistochemistry (IHC) (8), Immunoprecipitation (IP) (3), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunoelectron Microscopy (IEM) (1)
|
|
Conjugates
|
Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
|
|
Epitopes
|
C-Term (3), N-Term (3), Center (2), Middle (1), N-Term K187 (1)
|
