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Details for Product No. ABIN499599

Chemokine (C-C Motif) Receptor 3 (CCR3) (N-Term) antibody

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Antigen
Synonyms CC-CKR-3, CD193, CKR3, CMKBR3, Cmkbr3, CC-CKR3, Cmkbr1l2
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN499599
Quantity 0.1 mg
Price
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Human CCR3 (N-Terminus) Peptide (AP30216CP-N)
Isotype IgG
Specificity CCR3 antibody was raised against a 14 amino acid peptide from near the amino terminus of human CCR3.
Purification Immunoaffinity
Alternative Name CD193 / CCR3
Background Human immunodeficiency virus (HIV) and related virus require coreceptors to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b, CCR8, GPR15, STRL33, and CX3CR1 in the chemokine receptor family were recently identified as HIV coreceptors. CCR5, CXCR4 and CCR3 are the principal receptors for HIV fusion and entry of target cells (1-4). CCR3 facilitates infection by a subset of virus. CCR3 and CCR5 promote efficient infection of microglia, the major target cells in the CNS (3,4). High levels of CCR3 and CXCR4 expression were found on the neurons from both the central and peripheral nervous systems (5). The CCR3 ligand, eotaxin, and an anti-CCR3 antibody inhibited HIV infection of microglia. These results indicate CCR3 plays an important role in HIV infection of CNS.
Alternate names: C-C CKR-3, C-C chemokine receptor type 3, CC-CKR-3, CCR-3, CKR3, CMKBR3, Eosinophil eotaxin receptor
Gene ID 1232
NCBI Accession NP_847899
UniProt P51677
Research Area Chemokines, Receptors, CD Antigens
Application Notes ELISA. Western Blot: CCR3 antibody can be used for the detection of CCR3 at 1 – 2 μg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Feng, Broder, Kennedy et al.: "HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor." in: Science (New York, N.Y.), Vol. 272, Issue 5263, pp. 872-7, 1996 (PubMed).

Deng, Liu, Ellmeier et al.: "Identification of a major co-receptor for primary isolates of HIV-1." in: Nature, Vol. 381, Issue 6584, pp. 661-6, 1996 (PubMed).

Choe, Farzan, Sun et al.: "The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates." in: Cell, Vol. 85, Issue 7, pp. 1135-48, 1996 (PubMed).

He, Chen, Farzan et al.: "CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia." in: Nature, Vol. 385, Issue 6617, pp. 645-9, 1997 (PubMed).

Alternatives for antigen "Chemokine (C-C Motif) Receptor 3 (CCR3)", type "Antibodies"
Hosts (75), (16), (8), (3)
Reactivities (94), (33), (32), (13), (12)
Applications (55), (34), (29), (21), (20), (10), (9), (5), (1), (1), (1), (1)
Conjugates (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (16), (16), (5), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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