Chemokine (C-C Motif) Receptor 3 (CCR3) (N-Term) antibody

Antigen: Chemokine (C-C Motif) Receptor 3 (CCR3)

Synonyms: CKR3, CD193, CMKBR3, CC-CKR-3, MGC102841

Epitope: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Enzyme Immunoassay (EIA), Western Blotting (WB)

Catalog no.: ABIN499599

Additional Information

Characteristics: Synonyms: C-C chemokine receptor type 3, C-C CKR-3, CC-CKR-3, CCR-3, CKR3, CMKBR3, Eosinophileotaxin receptor

Alternative name: CD193 / CCR3

Gene ID: 1232

Swiss-Prot: P51677

Immunogen: Human CCR3 (N-Terminus) Peptide (ABIN499598)

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Isotype: IgG  (Matching secondary antibodies)

Description: Human immunodeficiency virus (HIV) and related virus require coreceptors to infect targetcells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b, CCR8,GPR15, STRL33, and CX3CR1 in the chemokine receptor family were recently identified asHIV coreceptors. CCR5, CXCR4 and CCR3 are the principal receptors for HIV fusion and entryof target cells (1-4). CCR3 facilitates infection by a subset of virus. CCR3 and CCR5 promoteefficient infection of microglia, the major target cells in the CNS (3,4). High levels of CCR3and CXCR4 expression were found on the neurons from both the central and peripheralnervous systems (5). The CCR3 ligand, eotaxin, and an anti-CCR3 antibody inhibited HIVinfection of microglia. These results indicate CCR3 plays an important role in HIV infectionof CNS.

Specificity: CCR3 antibody was raised against a 14 amino acid peptide from near the amino terminus ofhuman CCR3. Species: Human, Mouse, Rat. Others not tested. Add. Information: Blocking peptide available: blocking peptide (ABIN499598)

Application Details

Application Notes: ELISA. Western Blot: CCR3 antibody can be used for the detection of CCR3 at 1 – 2 μg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Purification: Aff - Purified

Buffer: PBS containing 0.02% sodium azide.

Storage: Store the antibody undiluted at 2-8°C. Shelf life: one year from despatch.

Restrictions: For Research Use only