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CCR3 antibody (Chemokine (C-C Motif) Receptor 3) (N-Term)

Details for Product anti-CCR3 Antibody No. ABIN499599, Supplier: Log in to see
Antigen
  • CC-CKR-3
  • CD193
  • CKR3
  • CMKBR3
  • CC-CKR3
  • Cmkbr1l2
  • Cmkbr3
Epitope
N-Term
24
22
14
13
10
6
5
3
3
3
3
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
153
45
30
1
Host
Rabbit
110
35
16
10
Clonality
Polyclonal
Conjugate
This CCR3 antibody is un-conjugated
17
9
8
5
4
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
92
52
48
44
35
11
11
6
4
4
2
2
2
2
1
1
Supplier
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Immunogen Human CCR3 (N-Terminus) Peptide
Isotype IgG
Specificity CCR3 antibody was raised against a 14 amino acid peptide from near the amino terminus of human CCR3.
Purification Immunoaffinity
Alternative Name CD193 / CCR3 (CCR3 Antibody Abstract)
Background Human immunodeficiency virus (HIV) and related virus require coreceptors to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b, CCR8, GPR15, STRL33, and CX3CR1 in the chemokine receptor family were recently identified as HIV coreceptors. CCR5, CXCR4 and CCR3 are the principal receptors for HIV fusion and entry of target cells (1-4). CCR3 facilitates infection by a subset of virus. CCR3 and CCR5 promote efficient infection of microglia, the major target cells in the CNS (3,4). High levels of CCR3 and CXCR4 expression were found on the neurons from both the central and peripheral nervous systems (5). The CCR3 ligand, eotaxin, and an anti-CCR3 antibody inhibited HIV infection of microglia. These results indicate CCR3 plays an important role in HIV infection of CNS.Synonyms: C-C CKR-3, C-C chemokine receptor type 3, CC-CKR-3, CCR-3, CKR3, CMKBR3, Eosinophil eotaxin receptor
Gene ID 1232
NCBI Accession NP_847899
UniProt P51677
Research Area Chemokines, Receptors, CD Antigens
Pathways
Application Notes ELISA. Western Blot: CCR3 antibody can be used for the detection of CCR3 at 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Western Blotting (WB) image for anti-CCR3 antibody (Chemokine (C-C Motif) Receptor 3) (N-Term) (ABIN499599) Western blot analysis of CCR3 in human spleen tissue lysates with AP30216PU-N CCR3 an...
Background publications He, Chen, Farzan et al.: "CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia." in: Nature, Vol. 385, Issue 6617, pp. 645-9, 1997 (PubMed).

Choe, Farzan, Sun et al.: "The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates." in: Cell, Vol. 85, Issue 7, pp. 1135-48, 1996 (PubMed).

Deng, Liu, Ellmeier et al.: "Identification of a major co-receptor for primary isolates of HIV-1." in: Nature, Vol. 381, Issue 6584, pp. 661-6, 1996 (PubMed).

Feng, Broder, Kennedy et al.: "HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor." in: Science (New York, N.Y.), Vol. 272, Issue 5263, pp. 872-7, 1996 (PubMed).