UBQLN4 antibody (N-Term)

Catalog No. ABIN499635

This anti-UBQLN4 antibody is a Rabbit Polyclonal antibody detecting UBQLN4 in WB, IHC (p) and EIA. Suitable for Human, Mouse and Rat.

Quick Overview for UBQLN4 antibody (N-Term) (ABIN499635)

Target: UBQLN4 (Ubiquilin 4 (UBQLN4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBQLN4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-UBQLN4 Antibody

Binding Specificity: N-Term

Specificity: This antibody reacts to CIP75.

Purification: Affinity chromatography purified via peptide column

Immunogen: CIP75 antibody was raised against an 18 amino acid peptide near the amino terminus of human CIP75.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: CIP75 antibody can be used for detection of CIP75 at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for UBQLN4

Target: UBQLN4 (Ubiquilin 4 (UBQLN4))

Alternative Name: Ubiquilin-4

Background: The ubiquitin-proteosome pathway of protein degradation is one of the mechanisms that ensure the proper level of cellular proteins. The ubiquitin-like (UbL) and ubiquitin-associated (UBA) domain containing protein family is thought to be involved in proteosomal degradation. One such protein is CIP75, also known as ubiquilin-4, interacts with a number of proteins such as Ataxin-1 and Connexin-43, resulting in an increased rate of turnover of these proteins. Overexpression CIP75 led to a significant reduction of Connexin-43 half-life, with the opposite being observed in siRNA knockdown experiments. CIP75 contains an N-terminal UbL domain which is thought to interact with proteins of the 26S proteosome complex and a C-terminal UBA domain which appears to mediate its interaction with Connexin-75. At least three isoforms of CIP75 are known to exist.Synonyms: A1Up, Ataxin-1 interacting ubiquitin-like protein, Ataxin-1 ubiquitin-like-interacting protein A1U, C1orf6, CIP75, Connexin43-interacting protein of 75 kDa, UBIN, UBQLN4

Gene ID: 56893

UniProt: Q9NRR5