CASP8 and FADD-Like Apoptosis Regulator (CFLAR) (C-Term) antibody

Details for Product No. ABIN499848
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Antigen
Synonyms
Clarp1, cflar, CFLAR, FLIP, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, 2310024N18Rik, A430105C05Rik, Cash, ENSMUSG00000072980, Flip, Gm984 ... show more
Clarp1, cflar, CFLAR, FLIP, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, 2310024N18Rik, A430105C05Rik, Cash, ENSMUSG00000072980, Flip, Gm9845, c-Flip show less
Epitope
C-Term
(42), (21), (11), (10), (9), (6), (6), (4), (4), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(167), (76), (53), (26), (26), (26), (12), (3), (1)
Host
Rabbit
(146), (43), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(153), (71), (50), (32), (27), (27), (20), (13), (11), (5), (4), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN499848
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Immunogen FLIP antibody was raised against a peptide corresponding to amino acids near the C- terminus of human FLIPaFLIPl form.
Isotype IgG
Specificity FLIP antibody was raised against a peptide corresponding to amino acids near the C- terminus of human FLIPaFLIPl form. Antibody recognizes the FLIPa only.
Purification DEAE
Alternative Name CFLAR / Casper / I-FLICE
Background Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP, respectively1,2. The human FLIP was also cloned by several labs independently and termed Casper , I-FLICE, FLAME-1, CASH and CLARP3-7. FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and 10, and potently inhibits apoptosis induced by all known death receptors. Four splice variants of c-FLIPs have been identified and termed FLIPalpha, beta, gamma, and delta, respectively (8).
Alternate names: CASH, CASP8 and FADD-like apoptosis regulator, CASP8AP1, CLARP, Caspase homolog, Caspase-eight-related protein, Caspase-like apoptosis regulatory protein, Cellular FLICE- like inhibitory protein, FADD-like antiapoptotic molecule 1, FLAME-1, Inhibitor of FLICE, MACH-related inducer of toxicity, MRIT, Usurpin, c-FLIP
Gene ID 8837
UniProt O15519
Application Notes ELISA. Western Blot: 1/500 to 1/2000. A 55 kDa band can be detected. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Thome, Schneider, Hofmann et al.: "Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors." in: Nature, Vol. 386, Issue 6624, pp. 517-21, 1997 (PubMed).

Shu, Halpin, Goeddel: "Casper is a FADD- and caspase-related inducer of apoptosis." in: Immunity, Vol. 6, Issue 6, pp. 751-63, 1997 (PubMed).

Hu, Vincenz, Ni et al.: "I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis." in: The Journal of biological chemistry, Vol. 272, Issue 28, pp. 17255-7, 1997 (PubMed).

Irmler, Thome, Hahne et al.: "Inhibition of death receptor signals by cellular FLIP." in: Nature, Vol. 388, Issue 6638, pp. 190-5, 1997 (PubMed).

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