anti-TNFRSF12A antibody (Tumor Necrosis Factor Receptor Superfamily, Member 12A)

Details for Product anti-TNFRSF12A Antibody No. ABIN499851
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Synonyms CD266, FN14, TWEAKR, AI255180, C87282, Fn14, HPIP, TWEAK-R, TweakR
(112), (44), (27)
(58), (55), (2)
This TNFRSF12A antibody is un-conjugated
(14), (7), (7), (3), (3), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(58), (50), (20), (19), (17), (10), (8), (4), (4), (2), (1), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Request Want additional data for this product?

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Immunogen Fn14 antibody was raised against a human IgG1 Fc-tagged Fn14 protein.
Isotype IgG
Specificity This antibody reacts to Fn14.
Purification Affinity chromatography purified via peptide column
Alternative Name CD266 / TweakR (TNFRSF12A Antibody Abstract)
Background TWEAK is a TNF family member produced by IFN-gamma-stimulated monocytes and induces multiple cell death pathways including caspase-dependent apoptosis and cathepsin B-dependent necrosis. These pathways are mediated by the binding of TWEAK by fibroblast growth factor 14 (Fn14), a member of the TNF receptor superfamily. Yeast two-hybrid experiments have shown that FN14 will bind to the TNFR-associated factors TRAF1, TRAF2, TRAF3, and TRAF5, suggesting that the signaling pathway induced by TWEAK may be mediated by one or more of these adaptor molecules. Fn14 is induced during liver regeneration and is highly expressed in hepatocellular carcinomas. In addition, TWEAK induces liver progenitor cell proliferation, suggesting Fn14 may play a role in hepatocyte growth control and liver neoplasia.Synonyms: FGF-inducible 14, FN14, Fibroblast growth factor-inducible immediate-early response protein 14, TNFRSF12A, Tumor necrosis factor receptor superfamily member 12A, Tweak receptor
Gene ID 51330
NCBI Accession NP_057723
UniProt Q9NP84
Research Area Receptors
Pathways Apoptosis Pathway
Application Notes ELISA. Western BLot: 2-4 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Background publications Brown, Richards, Hanscom et al.: "The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation." in: The Biochemical journal, Vol. 371, Issue Pt 2, pp. 395-403, 2003 (PubMed).

Nakayama, Ishidoh, Kojima et al.: "Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 1, pp. 341-8, 2002 (PubMed).

Feng, Guo, Factor et al.: "The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas." in: The American journal of pathology, Vol. 156, Issue 4, pp. 1253-61, 2000 (PubMed).

Chicheportiche, Bourdon, Xu et al.: "TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis." in: The Journal of biological chemistry, Vol. 272, Issue 51, pp. 32401-10, 1998 (PubMed).

Validation Images
Catalog No. ABIN499851
$ 401.50
Plus shipping costs $45.00
0.1 mg
$ 401.50

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