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Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) antibody

Details for Product No. ABIN499851
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Antigen
Synonyms CD266, FN14, TWEAKR, AI255180, C87282, Fn14, HPIP, TWEAK-R, TweakR
Reactivity
Human
(77), (28), (19), (17), (17)
Host
Rabbit
(52), (25), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (5), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(44), (37), (21), (15), (14), (12), (5), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN499851
401.50 $
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Immunogen Fn14 antibody was raised against a human IgG1 Fc-tagged Fn14 protein. (AP30344CP-N)
Isotype IgG
Specificity This antibody reacts to Fn14.
Purification Affinity chromatography purified via peptide column
Alternative Name CD266 / TweakR
Background TWEAK is a TNF family member produced by IFN-gamma-stimulated monocytes and induces multiple cell death pathways including caspase-dependent apoptosis and cathepsin B- dependent necrosis. These pathways are mediated by the binding of TWEAK by fibroblast growth factor 14 (Fn14), a member of the TNF receptor superfamily. Yeast two-hybrid experiments have shown that FN14 will bind to the TNFR-associated factors TRAF1, TRAF2, TRAF3, and TRAF5, suggesting that the signaling pathway induced by TWEAK may be mediated by one or more of these adaptor molecules. Fn14 is induced during liver regeneration and is highly expressed in hepatocellular carcinomas. In addition, TWEAK induces liver progenitor cell proliferation, suggesting Fn14 may play a role in hepatocyte growth control and liver neoplasia.
Alternate names: FGF-inducible 14, FN14, Fibroblast growth factor-inducible immediate-early response protein 14, TNFRSF12A, Tumor necrosis factor receptor superfamily member 12A, Tweak receptor
Gene ID 51330
NCBI Accession NP_057723
UniProt Q9NP84
Research Area Receptors
Application Notes ELISA. Western BLot: 2-4 μg/ml. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Chicheportiche, Bourdon, Xu et al.: "TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis." in: The Journal of biological chemistry, Vol. 272, Issue 51, pp. 32401-10, 1998 (PubMed).

Feng, Guo, Factor et al.: "The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas." in: The American journal of pathology, Vol. 156, Issue 4, pp. 1253-61, 2000 (PubMed).

Nakayama, Ishidoh, Kojima et al.: "Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 1, pp. 341-8, 2002 (PubMed).

Brown, Richards, Hanscom et al.: "The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation." in: The Biochemical journal, Vol. 371, Issue Pt 2, pp. 395-403, 2003 (PubMed).

Validation Images
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