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Glycoprotein VI (Platelet) (GP6) (Center) antibody

Details for Product No. ABIN499918
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Antigen
Synonyms 9830166G18Rik, Gm469, Gpvi, BDPLT11, GPIV, GPVI
Epitope
Center
(15), (5), (3), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(53), (13), (13)
Host
Rabbit
(53)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(39), (24), (15), (9), (7), (6), (2), (2)
Pubmed 5 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN499918
357.50 $
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Immunogen GPVI antibody was raised against a 18 amino acid peptide near the center of the Human GPVI. (AP30379CP-N)
Isotype IgG
Specificity This antibody recognizes GPVI. Species Reactivity: Tested: Human, Mouse, Rat.
Purification Affinity Chromatography purified via peptide column
Alternative Name Platelet glycoprotein VI
Background Glycoprotein VI (GP6) is a 58kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. It is uniquely expressed by cells of the megakaryocytic/platelet lineage, and is a member of the immunoglobulin gene superfamily, closely related to Fc receptor gamma chain (FcR?) and natural killer receptors. Glycoprotein VI plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR?, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. GPVI deficiency can result in bleeding disorders. Further study should reveal the extent of GPVI involvement in thrombotic disease and allow the development of alternative anti- thrombotic compounds.
Alternate names: GP6, GPVI, Glycoprotein 6
Gene ID 51206
NCBI Accession NP_057447
UniProt Q9HCN6
Application Notes ELISA. Western Blot: 1 μg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Clemetson, Polgar, Magnenat et al.: "The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors." in: The Journal of biological chemistry, Vol. 274, Issue 41, pp. 29019-24, 1999 (PubMed).

Jandrot-Perrus, Busfield, Lagrue et al.: "Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily." in: Blood, Vol. 96, Issue 5, pp. 1798-807, 2000 (PubMed).

Jarvis, Atkinson, Snell et al.: "Distinct roles of GPVI and integrin alpha(2)beta(1) in platelet shape change and aggregation induced by different collagens." in: British journal of pharmacology, Vol. 137, Issue 1, pp. 107-17, 2002 (PubMed).

Massberg, Gawaz, Grüner et al.: "A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo." in: The Journal of experimental medicine, Vol. 197, Issue 1, pp. 41-9, 2003 (PubMed).

Inoue, Suzuki-Inoue, Dean et al.: "Integrin alpha2beta1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCgamma2." in: The Journal of cell biology, Vol. 160, Issue 5, pp. 769-80, 2003 (PubMed).

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