Interleukin 31 (IL31) (N-Term) antibody

Details for Product No. ABIN500004
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Antigen
Synonyms IL31, IL-31, 1700013B14Rik
Epitope
N-Term
(17), (7), (4), (4), (2), (2), (1), (1), (1)
Reactivity
Mouse (Murine)
(69), (36), (13)
Host
Rabbit
(87), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(59), (40), (30), (20), (14), (9), (3), (3), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN500004
401.50 $
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Immunogen Murine IL-31 (N-Terminus) Peptide
Isotype IgG
Specificity IL-31 antibody was raised against a 16 amino acid peptide from near the amino terminus of mouse IL-31.
Purification Affinity chromatography purified via peptide column
Alternative Name Interleukin-31 / IL31
Background Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells (1,2). IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor (2). In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways (3). RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells . IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development (1,4).
Alternate names: IL-31
Gene ID 76399
UniProt Q6EAL8
Application Notes ELISA. Western Blot: 2.5 – 5 μg/ml. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Expiry Date 12 months
Background publications Dillon, Sprecher, Hammond et al.: "Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice." in: Nature immunology, Vol. 5, Issue 7, pp. 752-60, 2004 (PubMed).

Dreuw, Radtke, Pflanz et al.: "Characterization of the signaling capacities of the novel gp130-like cytokine receptor." in: The Journal of biological chemistry, Vol. 279, Issue 34, pp. 36112-20, 2004 (PubMed).

Diveu, Lak-Hal, Froger et al.: "Predominant expression of the long isoform of GP130-like (GPL) receptor is required for interleukin-31 signaling." in: European cytokine network, Vol. 15, Issue 4, pp. 291-302, 2005 (PubMed).

Bilsborough, Leung, Maurer et al.: "IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis." in: The Journal of allergy and clinical immunology, Vol. 117, Issue 2, pp. 418-25, 2006 (PubMed).

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