Interleukin 31 (IL31) (N-Term) antibody

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Synonyms IL31, IL-31, 1700013B14Rik
(25), (13), (12), (5), (4), (3), (3), (2), (2), (1), (1), (1), (1)
Mouse (Murine)
(103), (44), (19)
(122), (14), (1)
(19), (7), (6), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(83), (69), (30), (23), (22), (18), (6), (5), (5), (2), (2), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Murine IL-31 (N-Terminus) Peptide
Isotype IgG
Specificity IL-31 antibody was raised against a 16 amino acid peptide from near the amino terminus of mouse IL-31.
Purification Affinity chromatography purified via peptide column
Alternative Name Interleukin-31 / IL31 (IL31 Antibody Abstract)
Background Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells (1,2). IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor (2). In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways (3). RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells . IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development (1,4).Synonyms: IL-31
Gene ID 76399
UniProt Q6EAL8
Application Notes ELISA. Western Blot: 2.5 - 5 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Interleukin 31 (IL31) (N-Term) antibody (ABIN500004) Immunohistochemistry of IL-31 in rat skeletal muscle tissue with AP30422PU-N IL-31 an...
Western Blotting (WB) image for anti-Interleukin 31 (IL31) (N-Term) antibody (ABIN500004) Western blot analysis of IL-31 in RAW264.7 cell lysate with AP30422PU-N IL-31 antibod...
Background publications Bilsborough, Leung, Maurer et al.: "IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis." in: The Journal of allergy and clinical immunology, Vol. 117, Issue 2, pp. 418-25, 2006 (PubMed).

Diveu, Lak-Hal, Froger et al.: "Predominant expression of the long isoform of GP130-like (GPL) receptor is required for interleukin-31 signaling." in: European cytokine network, Vol. 15, Issue 4, pp. 291-302, 2005 (PubMed).

Dreuw, Radtke, Pflanz et al.: "Characterization of the signaling capacities of the novel gp130-like cytokine receptor." in: The Journal of biological chemistry, Vol. 279, Issue 34, pp. 36112-20, 2004 (PubMed).

Dillon, Sprecher, Hammond et al.: "Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. ..." in: Nature immunology, Vol. 5, Issue 7, pp. 752-60, 2004 (PubMed).

Catalog No. ABIN500004
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