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Baculoviral IAP Repeat-Containing 7 (BIRC7) (AA 264-280) antibody

Details for Product No. ABIN500182, Supplier: Login to see
Antigen
  • TIAP2
  • zgc:165605
  • EIAP/XLX
  • XLX
  • kiap
  • livin
  • ml-iap
  • mliap
  • rnf50
  • xEIAP
  • KIAP
  • LIVIN
  • ML-IAP
  • MLIAP
  • RNF50
  • RGD1562883
  • E130019N06
  • Livin
Epitope
AA 264-280
47
13
8
6
4
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
146
21
20
1
1
Host
Rabbit
103
24
20
Clonality
Polyclonal
Conjugate
Un-conjugated
5
4
3
3
3
3
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
119
57
40
28
11
11
6
5
4
2
2
1
1
1
1
1
1
1
Supplier
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Immunogen Livin antibody was raised with a synthetic peptide corresponding to amino acids 264 to 280 of the short form and 281 to 298 of the long form of human Livin (1,3). .Remarks: The sequence is identical between a and b forms of the Livin proteins.
Isotype IgG
Specificity This antibody detects BIRC7 / LIVIN.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Peptide affinity chromatography
Alternative Name BIRC7 / LIVIN (BIRC7 Antibody Abstract)
Background Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel member in the IAP protein family was recently identified and designated Livin and KIAP for kidney IAP (1,2). Livin/XIAP contains a single baculoviral IAP repeat (BIR) domain and a RING finger domain and has two isoforms termed Livin-a and Livin-b (1,3). Transfection of Livin in cells resulted in protection from apoptosis induced by FADD, BAX, RIP, RIP3 and DR6 (1). Livin has direct interaction with several caspases including caspase-3, -7, and -9. Livin inhibits the activation of caspase-9 induced by Apaf-1, cytochrome c, and dATP. The two isoforms of Livin appear to have different functions and tissue distributions.Synonyms: Baculoviral IAP repeat-containing protein 7, KIAP, Kidney inhibitor of apoptosis protein, Livin, MLIAP, Melanoma inhibitor of apoptosis protein, RING finger protein 50, RNF50
Gene ID 79444
NCBI Accession NP_071444
UniProt Q96CA5
Pathways
Application Notes ELISA. Western blot: 2 to 4 μg/mL. Human Raji cell lysate can be used as a positive control and aband at 33 kDa can be detected. A lower but much weaker band at 30 kDa was detected inRaji cell lysate, which may represent the short form of Livin. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Baculoviral IAP Repeat-Containing 7 (BIRC7) (AA 264-280) antibody (ABIN500182) Immunohistochemistry of Livin in human small intestine tissue with this product at 5 ...
Western Blotting (WB) image for anti-Baculoviral IAP Repeat-Containing 7 (BIRC7) (AA 264-280) antibody (ABIN500182) Western blot analysis of Livin expression in human Raji cell lysate with this product...
Background publications Ashhab, Alian, Polliack et al.: "Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern." in: FEBS letters, Vol. 495, Issue 1-2, pp. 56-60, 2001 (PubMed).

Lin, Deng, Huang et al.: "KIAP, a novel member of the inhibitor of apoptosis protein family." in: Biochemical and biophysical research communications, Vol. 279, Issue 3, pp. 820-31, 2001 (PubMed).

Kasof, Gomes: "Livin, a novel inhibitor of apoptosis protein family member." in: The Journal of biological chemistry, Vol. 276, Issue 5, pp. 3238-46, 2001 (PubMed).