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Details for Product No. ABIN500182

Baculoviral IAP Repeat-Containing 7 (BIRC7) (AA 264-280) antibody

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Antigen
Synonyms KIAP, LIVIN, MLIAP, RNF50, ML-IAP, Livin, E130019N06, TIAP2, RGD1562883, zgc:165605, EIAP/XLX, XLX, kiap, livin, ml-iap, mliap, rnf50, xEIAP
Epitope
»Alternatives AA 264-280
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN500182
Quantity 0.1 mg
Price
390.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Livin antibody was raised with a synthetic peptide corresponding to amino acids 264 to 280 of the short form and 281 to 298 of the long form of human Livin (1,3). .Remarks: The sequence is identical between a and b forms of the Livin proteins.
Isotype IgG
Specificity This antibody detects BIRC7 / LIVIN. Species Reactivity: Tested: Human
Purification Peptide affinity chromatography
Alternative Name BIRC7 / LIVIN
Background Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel member in the IAP protein family was recently identified and designated Livin and KIAP for kidney IAP (1,2). Livin/XIAP contains a single baculoviral IAP repeat (BIR) domain and a RING finger domain and has two isoforms termed Livin-a and Livin-b (1,3). Transfection of Livin in cells resulted in protection from apoptosis induced by FADD, BAX, RIP, RIP3 and DR6 (1). Livin has direct interaction with several caspases including caspase-3, -7, and -9. Livin inhibits the activation of caspase-9 induced by Apaf-1, cytochrome c, and dATP. The two isoforms of Livin appear to have different functions and tissue distributions.
Alternate names: Baculoviral IAP repeat-containing protein 7, KIAP, Kidney inhibitor of apoptosis protein, Livin, MLIAP, Melanoma inhibitor of apoptosis protein, RING finger protein 50, RNF50
Gene ID 79444
NCBI Accession NP_071444
UniProt Q96CA5
Application Notes ELISA. Western blot: 2 to 4 μg/ml. Human Raji cell lysate can be used as a positive control and aband at 33 kDa can be detected. A lower but much weaker band at 30 kDa was detected inRaji cell lysate, which may represent the short form of Livin. Immunohistochemistry on paraffin sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Kasof, Gomes: "Livin, a novel inhibitor of apoptosis protein family member." in: The Journal of biological chemistry, Vol. 276, Issue 5, pp. 3238-46, 2001 (PubMed).

Lin, Deng, Huang et al.: "KIAP, a novel member of the inhibitor of apoptosis protein family." in: Biochemical and biophysical research communications, Vol. 279, Issue 3, pp. 820-31, 2001 (PubMed).

Ashhab, Alian, Polliack et al.: "Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern." in: FEBS letters, Vol. 495, Issue 1-2, pp. 56-60, 2001 (PubMed).

Alternatives for antigen "Baculoviral IAP Repeat-Containing 7 (BIRC7)", type "Antibodies"
Hosts (71), (16), (12)
Reactivities (98), (16), (16), (13), (13)
Applications (83), (28), (26), (10), (10), (7), (5), (5), (5), (4), (3), (2), (2), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (14), (5), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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