STING/TMEM173 antibody (C-Term)

Catalog No. ABIN500288

The Rabbit Polyclonal anti-STING/TMEM173 antibody has been validated for WB, IF and EIA. It is suitable to detect STING/TMEM173 in samples from Human and Mouse.

Quick Overview for STING/TMEM173 antibody (C-Term) (ABIN500288)

Target: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STING/TMEM173 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-STING/TMEM173 Antibody

Binding Specificity: C-Term

Specificity: This antibody detects TMEM173 / STING.

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse.

Purification: Peptide Affinity Chromatography

Immunogen: TMEM173 antibody was raised against a 17 amino acid peptide near the carboxy terminus of Human TMEM173.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: (1-2 μg/mL). A-20 cell tissue lysate can be used as positive control. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for STING/TMEM173

Target: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Alternative Name: TMEM173 / STING

Background: MPYS (TMEM173 / STING) is a recently identified plasma membrane tetraspanner that is associated with major histocompatibility complex class II (MHC-II) and mediates its transduction of apoptotic signals. It has also been found to be associated with VISA, a mitochondrial protein that acts as an adaptor in virus-triggered signaling. MPYS also interacts with IRF3 and recruits the kinase TBK1 to the VISA-associated complex, acting as a critical mediator of virus-triggered IRF3 activation and interferon (IFN) expression. It is thought that the binding of nucleic acid to the innate immune protein RIG-I causes complex formation between RIG-I, VISA, and MPYS. This complex then recruits TBK1 to phosphorylate IRF3 which then directly activates IFN transcription. At least three isoforms of MPYS are known to exist.Synonyms: MITA, Mediator of IRF3 activation, Stimulator of interferon genes protein, Transmembrane protein 173

Gene ID: 340061

NCBI Accession: NP_938023

UniProt: Q86WV6

Pathways: Activation of Innate immune Response