Neurturin (NRTN) (AA 178-193) antibody

Details for Product No. ABIN500336
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Antigen
Synonyms NRTN, NTN
Epitope
AA 178-193
(10), (6), (5), (4), (2)
Reactivity
Human
(61), (20), (14), (12), (12)
Host
Rabbit
(48), (9), (4), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(54), (30), (12), (10), (6), (3), (3), (2), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN500336
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Immunogen Neurturin antibody was raised against a peptide corresponding to amino acids 178 to 193 of human neurturin.
Isotype IgG
Specificity This antibody detects Neurturin.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Peptide affinity chromatography
Alternative Name Neurturin
Background Glial cell line-derived neurotrophic factor (GDNF) plays key roles in the control of vertebrate neuron survival and differentiation. A novel neurotrophic factor was recently cloned from human and mouse and designated neurturin. Physiological responses to neurturin (NTN) require the presence of receptor tyrosine kinase RET and a novel glycosylphosphatidylinositol linked receptor NTNRalpha. The cDNAs encoding NTNRalpha from human, rat, chicken, and mouse have been cloned recently (3-8) and termed GDNFRb, Ret ligand 2 (RETL2) or TGF-Β-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRalpha-2 recently. NTN binds to and forms a complex with GFRalpha-2 and the Ret PTK and activates the RET receptor tyrosine kinase pathway. Both NTN and GDNF can activate the MAP kinase and phosphatidylinositol 3-kinase pathways and play a critical role in the development of many neuronal populations. Neurturin and GDNF define a new family of neurotrophic factors.Synonyms: NRTN
Gene ID 4902
NCBI Accession NP_004549
UniProt Q99748
Research Area Neurology
Application Notes ELISA. Western blot. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Background publications Kotzbauer, Lampe, Heuckeroth et al.: "Neurturin, a relative of glial-cell-line-derived neurotrophic factor." in: Nature, Vol. 384, Issue 6608, pp. 467-70, 1997 (PubMed).

Klein, Sherman, Ho et al.: "A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor." in: Nature, Vol. 387, Issue 6634, pp. 717-21, 1997 (PubMed).

Buj-Bello, Adu, Piñón et al.: "Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase." in: Nature, Vol. 387, Issue 6634, pp. 721-4, 1997 (PubMed).

Heuckeroth, Kotzbauer, Copeland et al.: "Neurturin, a novel neurotrophic factor, is localized to mouse chromosome 17 and human chromosome 19p13.3." in: Genomics, Vol. 44, Issue 1, pp. 137-40, 1997 (PubMed).

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