RIMS3 antibody (N-Term)

Catalog No. ABIN500610

This anti-RIMS3 antibody is a Rabbit Polyclonal antibody detecting RIMS3 in WB, IHC (p) and EIA. Suitable for Human and Mouse.

Quick Overview for RIMS3 antibody (N-Term) (ABIN500610)

Target: RIMS3 (Regulating Synaptic Membrane Exocytosis 3 (RIMS3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RIMS3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-RIMS3 Antibody

Binding Specificity: N-Term

Specificity: This antibody detects Rim3 at N-term. It is predicted to have no cross-reactivity to other Rim proteins.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse

Purification: Peptide affinity chromatography

Immunogen: Rim3 antibody was raised against a 17 amino acid peptide from near the amino terminus of human Rim3.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for RIMS3

Target: RIMS3 (Regulating Synaptic Membrane Exocytosis 3 (RIMS3))

Alternative Name: RIMS3

Background: Rab3-interacting molecules (RIMs) are synaptic proteins are synaptic proteins necessary for neural transmission and plasticity. While both Rim1 and Rim 2 are thought to be effector proteins for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner, less is known of Rim3. Expression of Rim3 in PC12 cells induced a significant increase in calcium-triggered exocytosis, with no appreciable change in the baseline release, suggesting that it plays a role in the regulation of exocytosis. Rim3 protein localizes primarily to neuronal dendrites and the postsynaptic densities, as opposed to Rim1 which is found in presynapse locations, indicating that Rim3 may contribute to synapse transmission and plasticity.Synonyms: KIAA0237, Nim3, RIM 3, RIM3 gamma, Rab-3-interacting molecule 3, Regulating synaptic membrane exocytosis protein 3

Gene ID: 9783

NCBI Accession: NP_055562

UniProt: Q9UJD0

Pathways: Stem Cell Maintenance, Synaptic Vesicle Exocytosis