SCO Cytochrome Oxidase Deficient Homolog 2 (Yeast) (SCO2) antibody

Antigen: SCO Cytochrome Oxidase Deficient Homolog 2 (Yeast) (SCO2)

Synonyms: SCO1L, MGC125823, MGC125825, SCO2, si:dkey-202b22.3, MGC165812, MGC28479

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Catalog no.: ABIN500688

Additional Information

Characteristics: Synonyms: Synthesis of cytochrome c oxidase 2, cytochrome oxidase deficient homolog 2

Alternative name: SCO2

Gene ID: 3184203

Swiss-Prot: Q5KW01

Immunogen: SCO2 antibody was raised against a 19 amino acid peptide from near the carboxy terminusof human SCO2.

Cross-Reactivity: Human

Isotype: IgG  (Matching secondary antibodies)

Description: Synthesis of cytochrome c oxidase 2 was initially identified in yeast as one of twocytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome choloenzyme, a complex that catalyzes the transfer of reducing equivalents fromcytochrome c to molecular oxygen and pumps protons across the inner mitochondrialmembrane. Like their yeast homologs, the function of both SCO2 and SCO1 are dependenton copper ion binding. Recent studies suggest that SCO2 expression is regulated by p53,so that a decrease in p53 expression, such as in numerous tumors and cells lines, the dropin SCO2 expression leads to a shift from normal aerobic respiration towards the productionof glycolytic ATP. Defects in the SCO2 protein are also associated with fatal infantilecardioencephalomyopathy and COX deficiency.

Specificity: This antibody detects SCO2. Species Reactivity: Tested: HumanAdd. Information: Blocking peptide available: ABIN500687

Application Details

Application Notes: ELISA. Western blot: 0.5 – 1 μg/ml. Immunohistochemistry on paraffin sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Purification: Aff - Purified

Buffer: PBS containing 0.02% sodium azide

Storage: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeatedfreezing and thawing. Shelf life: one year from despatch.

Research Area: Signaling, Metabolism, Organelles

Restrictions: For Research Use only