SLFN12 antibody (C-Term)

Catalog No. ABIN500746

This Rabbit Polyclonal antibody specifically detects SLFN12 in WB and EIA. It exhibits reactivity toward Human.

Quick Overview for SLFN12 antibody (C-Term) (ABIN500746)

Target: SLFN12 (Schlafen Family Member 12 (SLFN12))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLFN12 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-SLFN12 Antibody

Binding Specificity: C-Term

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Peptide affinity chromatography

Immunogen: SLFN12 antibody was raised against a 12 amino acid peptide from near the carboxy terminus human SLFN12.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for SLFN12

Target: SLFN12 (Schlafen Family Member 12 (SLFN12))

Alternative Name: SLFN12

Background: Despite being first described several years ago, the roles of the Schlafen (SLFN) family of proteins remain largely unknown. The SLFN genes are preferentially expressed in lymphoid tissues and differentially regulated during thymocyte maturation. It is thought that many play roles in cell growth, hemopoietic cell differentiation, and T cell development and maturation. Most members contain at least one divergent AAA domain (AAA_4) that may play a role in ATP binding. Although also known as SLFN3, a Schlafen family member that may be a marker of T cell activation, human SLFN12 has relatively low homology to SLFN3 in other species. Loss of the SLFN12 gene due to deletion is associated with Kabuki syndrome, a multiple congenital anomaly syndrome, suggesting SLFN may play a role in this genetic condition.Synonyms: Schlafen 12, Schlafen family member 12, Schlafen12

Gene ID: 55106

NCBI Accession: NP_060512

UniProt: Q8IYM2