TOLLIP antibody (Center)

Catalog No. ABIN501008

The Rabbit Polyclonal anti-TOLLIP antibody has been validated for WB, IF and EIA. It is suitable to detect TOLLIP in samples from Human, Mouse and Rat.

Quick Overview for TOLLIP antibody (Center) (ABIN501008)

Target: TOLLIP (Toll Interacting Protein (TOLLIP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TOLLIP antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-TOLLIP Antibody

Binding Specificity: Center

Specificity: This antibody detecs TOLLIP at Center.

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Rat

Purification: Peptide Affinity Chromatography

Immunogen: Human TOLLIP (Intermediate Domain) Peptide: A 16 amino acid peptide from near the center of Human TOLLIP.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 μg/mL. Immunoflourescence. Positive Controls: Rat Brain Tissue Lysate, THP-1 Cell Lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for TOLLIP

Target: TOLLIP (Toll Interacting Protein (TOLLIP))

Alternative Name: TOLLIP

Background: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The TLRs act through adaptor molecules to activate various kinases and transcription factors (3) so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation (4). This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.Synonyms: Toll-interacting protein

Gene ID: 54472