Two Pore Segment Channel 1 (TPCN1) (N-Term) antibody

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Antigen
Synonyms ATCCH1, ATTPC1, CALCIUM CHANNEL 1, FATTY ACID OXYGENATION UPREGULATED 2, FOU2, T5L23.5, two-pore channel 1, 5730403B01Rik, Tpc1, mKIAA1169, TPC1, si:dkey-125i10.5
Epitope
N-Term
(3), (3), (3), (2), (1)
Reactivity
Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus), Zebrafish (Danio rerio)
(11), (9), (6), (2)
Host
Rabbit
(14), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1)
Application
Western Blotting (WB)
(15), (5), (4), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the N terminal of human TPCN1
Blocking Peptide Blocking peptide for this product available: Two Pore Segment Channel 1 (TPCN1) (N-Term) peptide (ABIN985404)
Sequence YQEAAIYLQE GENNDKFFTH PKDAKALAAY LFAHNHLFYL MELATALLLL
Predicted Reactivity Bovine : 100 %, Chicken : 100 %, Dog : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Pig : 100 %, Rabbit : 100 %, Mouse : 90 %
Characteristics This is a rabbit polyclonal antibody against TPCN1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name TPCN1 (TPCN1 Antibody Abstract)
Background TPCN1 may function as one of the major voltage-gated Ca2+ channel (VDCC) across the plasma membrane.Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).
Molecular Weight 94 kDa
Gene ID 53373
NCBI Accession NP_060371, NM_017901
UniProt Q9ULQ1
Research Area Signaling
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 816 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Two Pore Segment Channel 1 (TPCN1) (N-Term) antibody (ABIN501390) WB Suggested Anti-TPCN1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
Background publications Clapham, Garbers: "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels." in: Pharmacological reviews, Vol. 57, Issue 4, pp. 451-4, 2005 (PubMed).

Catalog No. ABIN501390
$289.00
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