IRF4 antibody (Middle Region)

Catalog No. ABIN501643

This Rabbit Polyclonal antibody specifically detects IRF4 in WB. It exhibits reactivity toward Human, Rat, Dog, Guinea Pig and Horse.It has been mentioned in 1 publication

Quick Overview for IRF4 antibody (Middle Region) (ABIN501643)

Target: IRF4 (Interferon Regulatory Factor 4 (IRF4))

Reactivity: Human, Rat, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRF4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IRF4 Antibody

Binding Specificity: Middle Region

Sequence: TAHVEPLLAR QLYYFAQQNS GHFLRGYDLP EHISNPEDYH RSIRHSSIQE

Predicted Reactivity: Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against IRF4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human IRF4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 451 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-IRF4 antibody (ABIN501643)

Han, Kraft, Nan, Guo, Chen, Qureshi, Hankinson, Hu, Duffy, Zhao, Martin, Montgomery, Hayward, Thomas, Hoover, Chanock, Hunter: "A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation." in: PLoS genetics, Vol. 4, Issue 5, pp. e1000074, (2008) (PubMed).

Target Details for IRF4

Target: IRF4 (Interferon Regulatory Factor 4 (IRF4))

Alternative Name: IRF4

Background: IRF4 is a transcriptional activator. It binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter.It also binds the immunoglobulin lambda light chain enhancer, together with PU.1. IRF4 probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.
Alias Symbols: LSIRF, MUM1, NF-EM5
Protein Interaction Partner: UBC, STAT6, BCL6, TOP1, IRAK1, PRRC2B, YTHDC2, VPS35, PEG10, TLK2, CARM1, IKBKAP, ETV7, BATF, HOXB13, PROX1, HOXC11, FKBP4, SPIB, PRDM1, MYD88, TRAF2, NFATC2, SPI1,
Protein Size: 451

Molecular Weight: 52 kDa

Gene ID: 3662

NCBI Accession: NM_002460, NP_002451

UniProt: Q15306

Pathways: Chromatin Binding