TRAPPC2 antibody (Middle Region)

Catalog No. ABIN503168

The Rabbit Polyclonal anti-TRAPPC2 antibody has been validated for WB. It is suitable to detect TRAPPC2 in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse and Rabbit.

Quick Overview for TRAPPC2 antibody (Middle Region) (ABIN503168)

Target: TRAPPC2 (Trafficking Protein Particle Complex 2 (TRAPPC2))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRAPPC2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TRAPPC2 Antibody

Binding Specificity: Middle Region

Sequence: RQEDGIKNFF TDVYDLYIKF SMNPFYEPNS PIRSSAFDRK VQFLGKKHLL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against TRAPPC2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TRAPPC2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 140 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TRAPPC2

Target: TRAPPC2 (Trafficking Protein Particle Complex 2 (TRAPPC2))

Alternative Name: TRAPPC2

Background: TRAPPC2 prevents MBP1-mediated transcriptional repression and antagonizes MBP1-mediated cell death. TRAPPC2 may play a role in vesicular transport from endoplasmic reticulum to Golgi.The protein encoded by this gene is thought to be part of a large multisubunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind MBP1 and block its transcriptional repression capability. Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseuodogenes are found on chromosomes 8 and Y. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been found for this gene.
Alias Symbols: MIP-2A, SEDL, SEDT, TRS20, ZNF547L, hYP38334, MIP2A, TRAPPC2P1
Protein Interaction Partner: TRAPPC3L, TRAPPC5, TRAPPC6B, TRAPPC9, TRAPPC6A, TRAPPC11, TRAPPC4, TRAPPC12, TRAPPC3, TRAPPC8, TRAPPC10, ELAVL1, UBC, JOSD2, CLIC1, CLIC2, ENO1,
Protein Size: 140

Molecular Weight: 16 kDa

Gene ID: 6399

NCBI Accession: NM_014563, NP_055378

UniProt: O14582