Apolipoprotein E (APOE) antibody
| Antigen |
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| Synonyms |
AD2, LPG, LDLCQ5, MGC1571, AI255918, APOEA, APOE, ad2, apoprotein, MGC110064, im:7036787, wu:fb69a05, zgc:110064, apoe |
| Clonality |
Polyclonal |
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Host
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Reactivity
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Conjugate
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Biotin (9), HRP (3), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
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Application
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 Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Western Blotting (WB) (94), ELISA (82), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (25), Immunohistochemistry (IHC) (20), Immunofluorescence (IF) (15), Immunoprecipitation (IP) (10), Immunodiffusion (ID) (7), Immunohistochemistry (Frozen Sections) (IHC (fro)) (7), Immunoelectrophoresis (IEP) (6), Flow Cytometry (FACS) (5), Radioimmunoassay (RIA) (5), Enzyme Immunoassay (EIA) (4), Immunohistochemistry (Fixed) (IHC (fx)) (3), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunocytochemistry (ICC) (2), Radial Immunodiffusion (RID) (2), Dot Blot (Dot) (1), Immunoassay (IA) (1), Immunoelectron Microscopy (IEM) (1), Ouchterlony Double Diffusion (ODD) (1), Thin Layer Immunoassay (TIA) (1), To be determined by user (TBD) (1)
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| Catalog no. |
ABIN503507 |
| Quantity |
50 µg |
| Price |
317.90 $ Plus shipping costs $45.00
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Bulk discount
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| Shipping to |
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| Availability |
Will be delivered in 2 to 3 Business Days |
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Alternative name
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Apolipoprotein E (Apo E)
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Gene ID
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APOE
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UniProt
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P02649
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Immunogen
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The immunogen for anti-APOE antibody: synthetic peptide directed towards the N terminal of human APOE
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Sequence
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KVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSG QRWELALGRF
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Cross-Reactivity
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Human
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Format
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Lyophilized
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Reconstitution
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Add 50 µl of distilled water. Final anti-APOE antibody concentration is 1 mg/ml.
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Description
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Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
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Characteristics
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Antigen Size: 317 amino acids
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Molecular Weight
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34kDa
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Purification
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Affinity Purified
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Buffer
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PBS
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Storage (Long Term)
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For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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Storage (Short Term)
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Any unfrozen and/or unused material can be stored at 4°C for short term use (< 1 week), and should not be re-frozen.
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Research Area
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Metabolism
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Restrictions
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For Research Use only
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Product
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Ho, Niti, Yap et al.: "Metabolic syndrome and cognitive decline in chinese older adults: results from the singapore longitudinal ageing studies." in: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, Vol. 16, Issue 6, pp. 519-22, 2008 (PubMed).
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Alternatives for antigen "Apolipoprotein E (APOE)", type "Antibodies"
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Hosts
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Rabbit (67), Goat (55), Mouse (24)
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Reactivities
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Human (100), Mouse (Murine) (25), Rat (Rattus) (21), Rabbit (7), Hamster (4), Chimpanzee (1)
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Applications
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Western Blotting (WB) (94), ELISA (82), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (25), Immunohistochemistry (IHC) (20), Immunofluorescence (IF) (15), Immunoprecipitation (IP) (10), Immunodiffusion (ID) (7), Immunohistochemistry (Frozen Sections) (IHC (fro)) (7), Immunoelectrophoresis (IEP) (6), Flow Cytometry (FACS) (5), Radioimmunoassay (RIA) (5), Enzyme Immunoassay (EIA) (4), Immunohistochemistry (Fixed) (IHC (fx)) (3), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunocytochemistry (ICC) (2), Radial Immunodiffusion (RID) (2), Dot Blot (Dot) (1), Immunoassay (IA) (1), Immunoelectron Microscopy (IEM) (1), Ouchterlony Double Diffusion (ODD) (1), Thin Layer Immunoassay (TIA) (1), To be determined by user (TBD) (1)
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Conjugates
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Biotin (9), HRP (3), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
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Epitopes
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N-Term (5), C-Term (3), AA 140-160 (1)
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2013 BioMed Central Research Awards
