COX4I2 antibody (AA 21-104)

Catalog No. ABIN566588

There are 6+ publications for this product available. The Mouse Monoclonal anti-COX4I2 antibody is suitable to detect COX4I2 in samples from Human. It has been validated for WB, ELISA, IP and IHC (p).

Quick Overview for COX4I2 antibody (AA 21-104) (ABIN566588)

Target: COX4I2 (Cytochrome C Oxidase Subunit IV Isoform 2 (Lung) (COX4I2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This COX4I2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 1F2

Product Details anti-COX4I2 Antibody

Binding Specificity: AA 21-104

Purpose: Mouse monoclonal antibody raised against a partial recombinant COX4I2.

Sequence: MHSSEGTTRG GGKMSPYTNC YAQRYYPMPE EPFCTELNAE EQALKEKEKG SWTQLTHAEK VALYRLQFNE TFAEMNRRSN EWKT

Cross-Reactivity: Human, Rat

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: COX4I2 (NP_115998, 21 a.a. ~ 104 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-COX4I2 antibody (ABIN566588)

Schiffer, Peleli, Sundqvist, Ekblom, Lundberg, Weitzberg, Larsen: "Control of human energy expenditure by cytochrome c oxidase subunit IV-2." in: American journal of physiology. Cell physiology, Vol. 311, Issue 3, pp. C452-61, (2016) (PubMed).

Aras, Pak, Sommer, Finley, Hüttemann, Weissmann, Grossman: "Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2." in: Nucleic acids research, Vol. 41, Issue 4, pp. 2255-66, (2013) (PubMed).

Hüttemann, Lee, Gao, Pecina, Pecinova, Liu, Aras, Sommer, Sanderson, Tost, Neff, Aguilar-Pimentel, Becker, Naton, Rathkolb, Rozman, Favor, Hans, Prehn, Puk, Schrewe, Sun, Höfler, Adamski, Bekeredjian et al.: "Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology. ..." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 26, Issue 9, pp. 3916-30, (2012) (PubMed).

Sundar Boyalla, Barbara Victor, Roemgens, Beyer, Arnold: "Sex- and brain region-specific role of cytochrome c oxidase in 1-methyl-4-phenylpyridinium-mediated astrocyte vulnerability." in: Journal of neuroscience research, Vol. 89, Issue 12, pp. 2068-82, (2011) (PubMed).

Singh, Misiak, Beyer, Arnold: "Brain region specificity of 3-nitropropionic acid-induced vulnerability of neurons involves cytochrome c oxidase." in: Neurochemistry international, Vol. 57, Issue 3, pp. 297-305, (2010) (PubMed).

Misiak, Singh, Drewlo, Beyer, Arnold: "Brain region-specific vulnerability of astrocytes in response to 3-nitropropionic acid is mediated by cytochrome c oxidase isoform expression." in: Cell and tissue research, Vol. 341, Issue 1, pp. 83-93, (2010) (PubMed).

Target Details for COX4I2

Target: COX4I2 (Cytochrome C Oxidase Subunit IV Isoform 2 (Lung) (COX4I2))

Alternative Name: COX4I2

Background: Full Gene Name: cytochrome c oxidase subunit IV isoform 2 (lung)
Synonyms: COX4,COX4-2,COX4B,COX4L2,COXIV-2,dJ857M17.2

Gene ID: 84701

NCBI Accession: NM_032609

Pathways: Proton Transport