TCR alpha/beta antibody (APC)

Catalog No. ABIN567986

There are 5+ publications for this product available. The Mouse Monoclonal anti-TCR alpha/beta antibody is suitable to detect TCR alpha/beta in samples from Human. It has been validated for FACS.

Quick Overview for TCR alpha/beta antibody (APC) (ABIN567986)

Target: TCR alpha/beta (T Cell Receptor alpha/beta (TCR alpha/beta))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TCR alpha/beta antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Clone: IP26

Product Details anti-TCR alpha/beta Antibody (APC)

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Size-Exclusion Chromatography and adjusted for direct use

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS, 15 mM Sodium Azide, 0.2 % (w/v) high-grade protease free BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: DO NOT FREEZE! This products is photosensitive and should be protected from light.

Storage: 4 °C

Storage Comment: Store undiluted at 2-8 °C.

References for anti-TCR alpha/beta antibody (APC) (ABIN567986)

Kuttruff, Koch, Kelp, Pawelec, Rammensee, Steinle: "NKp80 defines and stimulates a reactive subset of CD8 T cells." in: Blood, Vol. 113, Issue 2, pp. 358-69, (2009) (PubMed).

Sullivan, Coscoy: "Downregulation of the T-cell receptor complex and impairment of T-cell activation by human herpesvirus 6 u24 protein." in: Journal of virology, Vol. 82, Issue 2, pp. 602-8, (2008) (PubMed).

Chentouf, Ghannam, Bès, Troadec, Cérutti, Chardès et al.: "Recombinant anti-CD4 antibody 13B8.2 blocks membrane-proximal events by excluding the Zap70 molecule and downstream targets SLP-76, PLC gamma 1, and Vav-1 from the CD4-segregated Brij 98 ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 1, pp. 409-20, (2007) (PubMed).

Ortonne, Huet, Gaudez, Marie-Cardine, Schiavon, Bagot, Musette, Bensussan: "Significance of circulating T-cell clones in Sezary syndrome." in: Blood, Vol. 107, Issue 10, pp. 4030-8, (2006) (PubMed).

Edwards, Grzyb, Dressler, Mansel, Zava, Sledge, McGuire: "Monoclonal antibody identification and characterization of a Mr 43,000 membrane glycoprotein associated with human breast cancer." in: Cancer research, Vol. 46, Issue 3, pp. 1306-17, (1986) (PubMed).

Target Details for TCR alpha/beta

Target: TCR alpha/beta (T Cell Receptor alpha/beta (TCR alpha/beta))

Alternative Name: T Cell Receptor / TCR alpha/beta

Background: The antigen-specific T cell receptor (TCR) is composed of either alpha and beta subunit, or gamma and delta subunit. Majority of T cells present in the blood, lymph and secondary lymphoid organs express TCR alpha/beta heterodimers, whereas the T cells expressing TCR gamma/delta heterodimers are localized mainly in epithelial tissues and at the sites of infection. The subunits of TCR heterodimers are covalently bonded and in the endoplasmic reticulum they associate with CD3 subunits to form functional TCR-CD3 complex. Lack of expression of any of the chains is sufficient to stop cell surface expression.