IL23A antibody

Catalog No. ABIN614363

There are 4+ publications for this product available. The Mouse Monoclonal anti-IL23A antibody is suitable to detect IL23A in samples from Human. It has been validated for WB, IP, IHC (p) and IHC (fro).

Quick Overview for IL23A antibody (ABIN614363)

Target: IL23A (Interleukin 23, alpha subunit p19 (IL23A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL23A antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: HLT2736

Product Details anti-IL23A Antibody

Specificity: Human recombinant p40 and p19 with elastin linker. The HLT2736 clone recognizes Human IL-23, a heterodimeric cytokine composed of the p40 subunit shared with IL-12 and a specific p19 subunit. This antibody recognizes heterodimeric IL-23, but does not react with the p40 subunit alone or recombinant IL-12(p70) when used as a Capture antibody in ELISA.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity Chromatography

Immunogen: Recombinant protein

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS, pH 7.2 containing 0.09 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

References for anti-IL23A antibody (ABIN614363)

Botbol, Patel, Macian: "Common γ-chain cytokine signaling is required for macroautophagy induction during CD4+ T-cell activation." in: Autophagy, Vol. 11, Issue 10, pp. 1864-77, (2015) (PubMed).

Muehlbauer, Lima, Goldman, Jacobson, Rivera, Goldberg, Palladino, Casadevall, Brojatsch: "Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin." in: The American journal of pathology, Vol. 177, Issue 2, pp. 735-43, (2010) (PubMed).

Katsifis, Rekka, Moutsopoulos, Pillemer, Wahl: "Systemic and local interleukin-17 and linked cytokines associated with Sjögren's syndrome immunopathogenesis." in: The American journal of pathology, Vol. 175, Issue 3, pp. 1167-77, (2009) (PubMed).

Gueirard, Ave, Balazuc, Thiberge, Huerre, Milon, Guiso: "Bordetella bronchiseptica persists in the nasal cavities of mice and triggers early delivery of dendritic cells in the lymph nodes draining the lower and upper respiratory tract." in: Infection and immunity, Vol. 71, Issue 7, pp. 4137-43, (2003) (PubMed).

Target Details for IL23A

Target: IL23A (Interleukin 23, alpha subunit p19 (IL23A))

Alternative Name: Interleukin-23 alpha / IL23A

Background: The p19 shares sequence similarity with IL-6 subfamily members and is distantly related to the p35 subunit of IL-12. It shows no biological activity by itself, instead, it combines with the p40 subunit of IL-12 to form a biologically active, composite cytokine, IL-23. IL-23 shares some in vivo functions with IL-12, including the activation of the transcription factor Stat4. Similar to IL-12, human IL-23 stimulates IFN-g production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death.Synonyms: IL-23 subunit alpha, IL-23p19, Interleukin-23 subunit p19, SGRF

Gene ID: 51561

NCBI Accession: NP_057668

UniProt: Q9NPF7

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation