Advanced Glycosylation End Product (AGE) antibody

Antigen: Advanced Glycosylation End Product (AGE)

Clonality: Polyclonal

Host: Goat

Application: ELISA, Western Blotting (WB)

Catalog no.: ABIN636761

Additional Information

Alternative name: AGE

Immunogen: AGE antibody was raised in goat using glycoaldehyde-modified protein as the immunogen.

Description: Glycation is a post-translational modification of proteins involving a covalent linkage between a reducing sugar, such as glucose, and a receptive amino group via the non-enzymatic Maillard reaction. During the early stages of the Maillard reaction, the aldehyde groups of the reducing sugars react with the amino groups of N-terminal amino acids to form Schiff bases, which are then converted to Amadori compounds. In the advanced stages, these Amadori compounds undergo oxidation, dehydration and condensation to form advanced glycation end-products (AGE) that are characterized by fluorescence, browning, and intra- or inter-molecular cross-linking properties. The main AGE products are pentosine and carboxymethyllysine (CML).

Application Details

Buffer: Supplied as liquid whole serum without preservative

Storage: Store at 4 °C for short term storage. Aliquot and store at -20 °C for long term storage. Avoid repeated freeze/thaw cycles.

Research Area: Cancer, Atherosclerosis, Metabolism