GABA(A) Receptor-Associated Protein-Like 2 (GABARAPL2) antibody

Details for Product No. ABIN650659
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Antigen
Synonyms GABARAPL2, atg8, gef2, gate16, gate-16, Gef2, ATG8, ATG8C, GATE-16, GATE16, GEF-2, GEF2, zgc:92319, 0610012F20Rik, 2900019O08Rik, AI173605
Reactivity
Human
(81), (21), (21), (13), (12), (1), (1), (1)
Host
Rabbit
(76), (3), (2), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(10), (10), (10), (5), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(55), (50), (39), (10), (8), (5), (2), (1)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN650659
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Immunogen This GABARAPL2 antibody is generated from rabbits immunized with human GABARAPL2 recombinant protein.
Clone RB22734
Isotype Ig
Specificity This GABARAPL2 antibody is generated from rabbits immunized with human GABARAPL2 recombinant protein.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name GABARAPL2
Background Membrane proteins located on vesicles (v-SNAREs) and on the target membrane (t-SNAREs) mediate specific recognition and, possibly, fusion between a transport vesicle and its target membrane. The activity of SNARE molecules is regulated by several soluble cytosolic proteins. We have cloned a bovine brain cDNA encoding a conserved 117 amino acid polypeptide, denoted Golgi-associated ATPase Enhancer of 16 kDa (GATE-16), that functions as a soluble transport factor. GATE-16 interacts with N-ethylmaleimidesensitive factor (NSF) and significantly stimulates its ATPase activity. It also interacts with the Golgi v-SNARE GOS-28 in an NSF-dependent manner. We propose that GATE-16 modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation.
Synonyms: GABA(A) receptor-associated protein-like 2, Ganglioside expression factor 2, GEF-2, General protein transport factor p16, MAP1 light chain 3-related protein
Molecular Weight 13536 DA
Gene ID 11345
UniProt P60520
Research Area Autophagy
Application Notes WB = 1:1000, IHC = 1:50-100, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-GABA(A) Receptor-Associated Protein-Like 2 (GABARAPL2) antibody Western blot analysis of GABARAPL2 Antibody (ABIN650659) in MCF-7 cell line lysates (35 µg/lane). GABARAPL2 (arrow) was detected using the purified polyclonal antibody.
anti-GABA(A) Receptor-Associated Protein-Like 2 (GABARAPL2) antibody (2) Formalin-fixed and paraffin-embedded mouse brain tissue reacted with GABARAPL2 Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
anti-GABA(A) Receptor-Associated Protein-Like 2 (GABARAPL2) antibody (3) GABARAPL2 Antibody (ABIN650659) FC analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Wiemann, Arlt, Huber et al.: "From ORFeome to biology: a functional genomics pipeline." in: Genome research, Vol. 14, Issue 10B, pp. 2136-44, 2004 (PubMed).

Sou, Tanida, Komatsu et al.: "Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16." in: The Journal of biological chemistry, Vol. 281, Issue 6, pp. 3017-24, 2006 (PubMed).

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