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tyrosine Kinase, Non-Receptor, 2 (TNK2) (pTyr826) antibody

Details for Product No. ABIN650839
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Antigen
Synonyms ACK, ACK-1, ACK1, p21cdc42Hs, AW552477, Ack, Cdgip, Pyk1
Epitope
pTyr826
(22), (22), (12), (12), (10), (8), (7), (7), (7), (6), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(137), (76), (63), (49), (49), (48), (12), (2)
Host
Rabbit
(136), (3), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(8), (8), (8), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Application
Dot Blot (DB)
(87), (74), (40), (20), (20), (17), (12), (5), (5), (3), (3)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN650839
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This ACK1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y826 of human ACK1.
Clone RB15411
Isotype Ig
Specificity This Phospho-ACK1-Y826 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between 814~844 amino acids surrounding Y826 of human ACK1.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ACK1
Background ACK1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway.
Synonyms: Tyrosine kinase non-receptor protein 2, Activated CDC42 kinase 1, ACK-1, ACK1, TNK2
Molecular Weight 114327 DA
Gene ID 10188
UniProt Q07912
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes DB = 1:500
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-tyrosine Kinase, Non-Receptor, 2 (TNK2) (pTyr826) antibody Dot blot analysis of anti-Phospho-ACK1-pY826 Phospho-specific Pab (ABIN650839) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL.
Background publications Goss, Lee, Moritz et al.: "A common phosphotyrosine signature for the Bcr-Abl kinase." in: Blood, Vol. 107, Issue 12, pp. 4888-97, 2006 (PubMed).

Wolf-Yadlin, Hautaniemi, Lauffenburger et al.: "Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 14, pp. 5860-5, 2007 (PubMed).

Huang, Mukasa, Bonavia et al.: "Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 31, pp. 12867-72, 2007 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN650839
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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