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Kallikrein 6 (KLK6) (N-Term), (AA 1-30) antibody

Details for Product No. ABIN652195
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Antigen
Synonyms klk6, KLK8, Klk1b21, Klk6, rGK-8, rk8, AI849898, BSP, Bssp, Klk29, MSP, Prss18, Prss9, neurosin, Klk7, PRSS18, PRSS9, SP59, hK6
Epitope
N-Term, AA 1-30
(4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(33), (16), (14), (1), (1)
Host
Rabbit
(28), (6), (5)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(26), (16), (10), (9), (6), (4), (3), (3), (2), (1), (1), (1), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN652195
291.50 $
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Immunogen This Kallikrein 6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human Kallikrein 6.
Clone RB6114
Isotype Ig
Specificity This Kallikrein 6 Antibody antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6~35 amino acids from the N-terminal region of human KLK6.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Background Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The KLK6 enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease.
Synonyms: Protease M, Neurosin, Zyme, SP59,
Molecular Weight 26856 DA
Gene ID 5653
UniProt Q92876
Research Area Neurology, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Kallikrein 6 (KLK6) (N-Term), (AA 1-30) antibody Western blot analysis of KLK6 (arrow) using rabbit polyclonal KLK6 Antibody (A13) (ABIN652195). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the KLK6 gene.
anti-Kallikrein 6 (KLK6) (N-Term), (AA 1-30) antibody (2) Kallikrein 6(KLK6) Antibody (N-term) (ABIN652195)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.
Background publications Sauter, Lininger, Magklara et al.: "Association of kallikrein expression in nipple aspirate fluid with breast cancer risk." in: International journal of cancer. Journal international du cancer, Vol. 108, Issue 4, pp. 588-91, 2003 (PubMed).

Pampalakis, Kurlender, Diamandis et al.: "Cloning and characterization of novel isoforms of the human kallikrein 6 gene." in: Biochemical and biophysical research communications, Vol. 320, Issue 1, pp. 54-61, 2004 (PubMed).

Ghosh, Grass, Soosaipillai et al.: "Human kallikrein 6 degrades extracellular matrix proteins and may enhance the metastatic potential of tumour cells." in: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, Vol. 25, Issue 4, pp. 193-9, 2004 (PubMed).

Validation Images
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