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Kallikrein 6 antibody (KLK6) (AA 227-244) Primary Antibody

KLK6 Reactivity: Human ICC, IHC (p), WB Host: Rabbit Polyclonal
Catalog No. ABIN3044157
$280.00
Plus shipping costs $45.00
100 μg
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  • Target
    Binding Specificity
    AA 227-244, C-Term
    Reactivity
    Human
    Host
    Rabbit
    Clonality
    Polyclonal
    Conjugate
    This Kallikrein 6 antibody is un-conjugated
    Application
    Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Purpose
    Rabbit IgG polyclonal antibody for Kallikrein-6(KLK6) detection. Tested with WB, IHC-P, ICC in Human.
    Sequence
    YTNVCRYTNW IQKTIQAK
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for Kallikrein-6(KLK6) detection. Tested with WB, IHC-P, ICC in Human.
    Gene Name: kallikrein-related peptidase 6
    Protein Name: Kallikrein-6
    Purification
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminus of human Kallikrein 6(227-244aa YTNVCRYTNWIQKTIQAK).
    Isotype
    IgG
  • Target
    Alternative Name
    KLK6 (KLK6 Antibody Abstract)
    Background
    KLK6(Kallikrein-related peptidase 6), also called KALLIKREIN 6, NEUROSIN, PROTEASE M, ZYME or PRSS9, is a protein that in humans is encoded by the KLK6 gene. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. Northern blot analysis revealed that the PRSS9 mRNA was expressed in several primary tumors and cell lines from mammary, prostate, and ovarian cancers, but was not detected in any metastases of these cancers. The KLK6 gene is mapped on 19q13.41. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Upon cellular stress, neurosin was released from mitochondria to the cytosol, which resulted in the increase of degraded alpha-synuclein species. Neurosin may play a significant role in physiologic alpha-synuclein degradation and also in the pathogenesis of synucleinopathies.

    Synonyms: Bssp antibody|hK 6 antibody|hK6 antibody|Kallikrein 6 precursor antibody|Kallikrein related peptidase 6 antibody|Kallikrein-6 antibody|Kallikrein6 antibody|KLK 6 antibody|Klk 7 antibody|KLK 9 antibody|Klk29 antibody|Klk6 antibody|KLK6_HUMAN antibody|Klk7 antibody|KLK9 antibody|MGC9355 antibody|mGK 1 antibody|mGK1 antibody|MSP antibody|Neurosin antibody|Protease M antibody|Protease serine 18 antibody|Protease serine 9 antibody|PRSS 18 antibody|PRSS 9 antibody|PRSS18 antibody|PRSS9 antibody|Serine protease 18 antibody|Serine protease 9 antibody|SP 59 antibody|SP59 antibody|Tissue kallikrein antibody|TK antibody|Zyme antibody
    UniProt
    Q92876
    Pathways
    Complement System, Regulation of G-Protein Coupled Receptor Protein Signaling
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Preservative
    Thimerosal (Merthiolate), Sodium azide
    Precaution of Use
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    Expiry Date
    12 months
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