Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

Kallikrein 6 antibody (KLK6) (N-Term) Primary Antibody

KLK6 Reactivity: Dog, Horse, Human IHC, WB Host: Rabbit Polyclonal
Catalog No. ABIN2778179
$229.00
Plus shipping costs $45.00
100 μL
local_shipping Shipping to: United States
Delivery in 2 to 3 Business Days
  • Target
    Binding Specificity
    N-Term
    Reactivity
    Dog, Horse, Human
    Host
    Rabbit
    Clonality
    Polyclonal
    Conjugate
    This Kallikrein 6 antibody is un-conjugated
    Application
    Immunohistochemistry (IHC), Western Blotting (WB)
    Blocking Peptide
    Blocking peptide for this product available: ABIN979080
    Sequence
    KHNLRQRESS QEQSSVVRAV IHPDYDAASH DQDIMLLRLA RPAKLSELIQ
    Predicted Reactivity
    Dog: 92%, Horse: 92%, Human: 100%
    Characteristics
    This is a rabbit polyclonal antibody against KLK6. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human KLK6
  • Target
    Alternative Name
    KLK6 (KLK6 Antibody Abstract)
    Background
    Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The gene that encodes KLK6 protein is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. KLK6 is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease.Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene.
    Alias Symbols: Bssp, Klk7, MGC9355, NEUROSIN, PRSS18, PRSS9, SP59, ZYME, hK6
    Protein Interaction Partner: SNCA, SERPINF2, SERPINC1,
    Protein Size: 244
    Molecular Weight
    25 kDa
    Gene ID
    5653
    NCBI Accession
    NM_001012964, NP_001012982
    UniProt
    Q92876
    Pathways
    Complement System, Regulation of G-Protein Coupled Receptor Protein Signaling
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 244 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
You are here:
help Support