Chromosome 11 Open Reading Frame 30 (C11orf30) (N-Term) antibody

Antigen: Chromosome 11 Open Reading Frame 30 (C11orf30)

Synonyms: EMSY, GL002, FLJ90741, 2210018M11RIK

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN653429

Additional Information

Alternative name: C11orf30

Gene ID: 56946

UniProt: Q7Z589

Immunogen: This C11orf30 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53~83 amino acids from the N-terminal region of human C11orf30.

Isotype: Ig

Description: Other names: Protein EMSY, GL002, C11orf30, EMSY

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This C11orf30 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53~83 amino acids from the N-terminal region of human C11orf30.

Molecular Weight: 141468 DA

Comments:

Background: Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cancer, Transcription Factors, Signaling, Cell Structure

Restrictions: For Research Use only

Images

Western blot analysis of C11orf30 Antibody (N-term) (ABIN653429) in Ramos cell line lysates (35ug/lane). C11orf30 (arrow) was detected using the purified Pab.

Publications

Product: Vega, Salas, Milne et al.: "Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study." in: Gynecologic oncology, Vol. 112, Issue 1, pp. 210-4, 2008 (PubMed).

Mavaddat, Dunning, Ponder et al.: "Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 1, pp. 255-9, 2009 (PubMed).

Garapaty, Xu, Trojer et al.: "Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation." in: The Journal of biological chemistry, Vol. 284, Issue 12, pp. 7542-52, 2009 (PubMed).

Esparza-Gordillo, Weidinger, Fölster-Holst et al.: "A common variant on chromosome 11q13 is associated with atopic dermatitis." in: Nature genetics, Vol. 41, Issue 5, pp. 596-601, 2009 (PubMed).