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AIM2 antibody (Absent in Melanoma 2) (AA 4-32)

Details for Product anti-AIM2 Antibody No. ABIN653833, Supplier: Log in to see
Antigen
  • AIM2
  • PYHIN4
  • Gm1313
  • Ifi210
Epitope
AA 4-32, N-Term
19
16
15
14
10
8
4
4
3
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human
137
23
20
1
1
Host
Rabbit
84
35
20
Clonality (Clone)
Polyclonal ()
Conjugate
This AIM2 antibody is un-conjugated
7
6
6
6
5
5
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
113
77
28
18
14
11
10
9
3
2
2
1
Supplier
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Immunogen This AIM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-32 AA from the N-terminal region of human AIM2.
Clone RB23659
Isotype Ig
Specificity This AIM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11~40 amino acids from the N-terminal region of human AIM2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name AIM2 (AIM2 Antibody Abstract)
Background AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.
Synonyms: Absent in melanoma 2, Interferon-inducible protein AIM2,AIM2
Molecular Weight 38954 DA
Gene ID 9447
UniProt O14862
Research Area Cancer, Cell Structure
Pathways
Application Notes WB = 1:1000, FACS = 1:10-50, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.47 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-AIM2 antibody (Absent in Melanoma 2) (AA 4-32) (ABIN653833) Western blot analysis of AIM2 Antibody (N-term) (ABIN653833) in MCF-7, HL-60, K562, H...
Flow Cytometry (FACS) image for anti-AIM2 antibody (Absent in Melanoma 2) (AA 4-32) (ABIN653833) AIM2 Antibody (N-term) (ABIN653833) flow cytometric analysis of MCF-7 cells (bottom h...
Background publications Patsos, Germann, Gebert et al.: "Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells." in: International journal of cancer. Journal international du cancer, Vol. 126, Issue 8, pp. 1838-49, 2010 (PubMed).

Hornung, Ablasser, Charrel-Dennis et al.: "AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC." in: Nature, Vol. 458, Issue 7237, pp. 514-8, 2009 (PubMed).

Woerner, Kloor, Schwitalle et al.: "The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers." in: Genes, chromosomes & cancer, Vol. 46, Issue 12, pp. 1080-9, 2007 (PubMed).

Cresswell, Clarke, Jackson et al.: "Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2." in: Biochemical and biophysical research communications, Vol. 326, Issue 2, pp. 417-24, 2004 (PubMed).