Peroxisomal Biogenesis Factor 1 (PEX1) (Center) antibody

Antigen: Peroxisomal Biogenesis Factor 1 (PEX1)

Binding Site: Center

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN654140

Additional Information

Alternative name: PEX1

Gene ID: 5189

UniProt: O43933, NP_000457.1

Immunogen: This PEX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 606-637 amino acids from the Central region of human PEX1.

Isotype: Ig

Description: Other names: Peroxisome biogenesis factor 1,PEX1,

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This PEX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 606-637 amino acids from the Central region of human PEX1.

Molecular Weight: 142867 DA

Comments:

Background: This gene encodes a member of the AAA ATPase family, a large group of ATPases associated with diverse cellular activities. This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis. Mutations in this gene have been associated with complementation group 1 peroxisomal disorders such as neonatal adrenoleukodystrophy, infantile Refsum disease, and Zellweger syndrome.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Cell Structure, Chromatin, Signaling

Restrictions: For Research Use only

Images

PEX1 Antibody (Center) (ABIN654140) western blot analysis in MCF-7 cell line lysates (35ug/lane). This demonstrates the PEX1 antibody detected the PEX1 protein (arrow).

Publications

Product: Tamura, Yasutake, Matsumoto et al.: "Dynamic and functional assembly of the AAA peroxins, Pex1p and Pex6p, and their membrane receptor Pex26p." in: The Journal of biological chemistry, Vol. 281, Issue 38, pp. 27693-704, 2006 (PubMed).

Matsuoka, Ballif, Smogorzewska et al.: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).

Zhao, Li, Bradfield et al.: "The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature." in: BMC medical genetics, Vol. 11, pp. 96, 2010 (PubMed).