ATP6V0C antibody (C-Term)

Catalog No. ABIN654427

This Rabbit Polyclonal antibody specifically detects ATP6V0C in WB. It exhibits reactivity toward Human and Mouse.

Quick Overview for ATP6V0C antibody (C-Term) (ABIN654427)

Target: ATP6V0C (ATPase, H+ Transporting, Lysosomal 16kDa, V0 Subunit C (ATP6V0C))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATP6V0C antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB24576

Product Details anti-ATP6V0C Antibody

Binding Specificity: AA 100-126, C-Term

Predicted Reactivity: E, B, D, Rat, Sh

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ATP6V0C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-126 amino acids from the C-terminal region of human ATP6V0C.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for ATP6V0C

Target: ATP6V0C (ATPase, H+ Transporting, Lysosomal 16kDa, V0 Subunit C (ATP6V0C))

Alternative Name: ATP6V0C

Background: ATP6V0C is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. ATP6V0C encodes the V0 subunit c.

Molecular Weight: 15736

Gene ID: 527

NCBI Accession: NP_001185498, NP_001685

UniProt: P27449

Pathways: Transition Metal Ion Homeostasis, Proton Transport