ORM1-Like 3 (S. Cerevisiae) (ORMDL3) (Center) antibody

Antigen: ORM1-Like 3 (S. Cerevisiae) (ORMDL3)

Binding Site: Center

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN654696

Additional Information

Alternative name: ORMDL3

Gene ID: 94103

UniProt: Q8N138, NP_644809.1

Immunogen: This ORMDL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-85 amino acids from the Central region of human ORMDL3.

Isotype: Ig

Description: Other names: ORM1-like protein 3,ORMDL3,

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This ORMDL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-85 amino acids from the Central region of human ORMDL3.

Molecular Weight: 17495 DA

Comments:

Background: Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Structure

Restrictions: For Research Use only

Images

ORMDL3 Antibody (Center) (ABIN654696) western blot analysis in mouse testis tissue lysates (35ug/lane). This demonstrates the ORMDL3 antibody detected the ORMDL3 protein (arrow).

Publications

Product: McGovern, Gardet, Törkvist et al.: "Genome-wide association identifies multiple ulcerative colitis susceptibility loci." in: Nature genetics, Vol. 42, Issue 4, pp. 332-7, 2010 (PubMed).

Halapi, Gudbjartsson, Jonsdottir et al.: "A sequence variant on 17q21 is associated with age at onset and severity of asthma." in: European journal of human genetics : EJHG, Vol. 18, Issue 8, pp. 902-8, 2010 (PubMed).

Fransen, Visschedijk, van Sommeren et al.: "Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease." in: Human molecular genetics, Vol. 19, Issue 17, pp. 3482-8, 2010 (PubMed).

Liu, Invernizzi, Lu et al.: "Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis." in: Nature genetics, Vol. 42, Issue 8, pp. 658-60, 2010 (PubMed).