Complement Factor H (CFH) (Center) antibody
| Antigen | Complement Factor H (CFH) |
| Synonyms | FH, HF, HF1, HF2, HUS, FHL1, AHUS1, ARMD4, ARMS1, CFHL3, MGC88246, NOM, Sas1, Mud-1, Sas-1, Fh, CFH, MGC129039, im:7147412, si:ch211-207o17.2 |
| Binding Site |
 Alternatives Center |
| Clonality | Polyclonal |
| Host |
Alternatives Rabbit |
| Reactivity |
Alternatives Human |
| Conjugate |
Alternatives Un-conjugated |
| Application |
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA |
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2 references available |
| Certificates | ISO 9001:2008 |
| Catalog no. | ABIN654896 |
| Quantity | 0.1 mg (0.25 mg/ml) |
| Price | 280.50 $ Plus shipping costs $45.00 |
| Shipping to |
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| Availability | Will be delivered in 2 to 3 Business Days |
Additional Information
| Alternative name | CFH |
| Gene ID | 3075 |
| UniProt | NP_000177.2, P08603 |
| Immunogen | This CFH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 751-780 amino acids from the Central region of human CFH. |
| Isotype | Ig |
| Description | Other names: Complement factor H,CFH,HF, HF1, HF2 |
| Characteristics | Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) |
| Specificity | This CFH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 751-780 amino acids from the Central region of human CFH. |
| Molecular Weight | 139096 DA |
| Comments |
Background: This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short concensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. |
Application Details
| Application Notes | The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500 Immunohistochemistry ~~ 1:50~100 |
| Concentration | 0.25 mg/ml |
| Purification | Purified |
| Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles |
| Research Area | Cell Signaling, Protein Modifications, Cell Structure |
| Restrictions | For Research Use only |
Publications
| Product |
Bunkenborg, Pilch, Podtelejnikov et al.: "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry." in: Proteomics, Vol. 4, Issue 2, pp. 454-65, 2004 (PubMed).
Scambi, La Verde, De Franceschi et al.: "Comparative proteomic analysis of serum from patients with systemic sclerosis and sclerodermatous GVHD. Evidence of defective function of factor H." in: PLoS ONE, Vol. 5, Issue 8, pp. e12162, 2010 (PubMed). |
Alternatives
Alternatives for antigen "Complement Factor H (CFH)", type "Antibodies"
