B-Cell CLL/lymphoma 7A (BCL7A) (N-Term) antibody

Antigen: B-Cell CLL/lymphoma 7A (BCL7A)

Synonyms: BCL7, cb585, MGC92023, sb:cb585, zgc:92023, id:ibd1097, wu:fk02d01, AI448316, 4432415N06Rik, bcl7a, MGC89576, BCL7A

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN654937

Additional Information

Alternative name: BCL7A

Gene ID: 605

UniProt: NP_001019979.1, NP_066273.1, Q4VC05

Immunogen: This BCL7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human BCL7A.

Isotype: Ig

Description: Other names: B-cell CLL/lymphoma 7 protein family member A,BCL7A,

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This BCL7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human BCL7A.

Molecular Weight: 22810 DA

Comments:

Background: This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Phospho-specific antibodies, Protein Modifications, Signaling, Chromatin, Cell Structure

Restrictions: For Research Use only

Images

BCL7A Antibody (N-term) (ABIN654937) western blot analysis in NCI-H292 cell line lysates (35ug/lane). This demonstrates the BCL7A antibody detected the BCL7A protein (arrow).

Publications

Product: Matsuoka, Ballif, Smogorzewska et al.: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).