Forkhead Box A2 (FOXA2) (C-Term) antibody

Antigen: Forkhead Box A2 (FOXA2)

Synonyms: HNF3B, TCF3B, MGC19807, Hnf3b, Tcf3b, Hnf-3b, Tcf-3b, HNF3beta, HNF3-beta, ax, axl, fkd1, HNF-3B, MGC101552, tdsubc_2g8, wu:fe05g04, ik:tdsubc_2g8, xx:tdsubc_2g8, hnf3b, tcf3b, hnf3beta, hnf3-beta, FOXA2, HNF-3BETA, HNF-3b, xFD-3, FoxA2a, FoxA2-A, xbeta-1

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN655970

Additional Information

Alternative name: FOXA2

Gene ID: 3170

UniProt: Q9Y261, NP_068556.2

Immunogen: This FOXA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 387-415 amino acids from the C-terminal region of human FOXA2.

Isotype: Ig

Description: Other names: FOXA2,Hepatocyte nuclear factor 3-beta,HNF3B, TCF3B

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This FOXA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 387-415 amino acids from the C-terminal region of human FOXA2.

Molecular Weight: 48306 DA

Comments:

Background: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene.

Synonyms: HNF3B, TCF3B, MGC19807, Hnf3b, Tcf3b, Hnf-3b, Tcf-3b, HNF3beta, HNF3-beta, ax, axl, fkd1, HNF-3B, MGC101552, tdsubc_2g8, wu:fe05g04, ik:tdsubc_2g8, xx:tdsubc_2g8, hnf3b, tcf3b, hnf3beta, hnf3-beta, FOXA2, HNF-3BETA, HNF-3b, xFD-3, FoxA2a, FoxA2-A, xbeta-1

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Signaling, Cell Structure

Restrictions: For Research Use only

Publications

Product: Xing, Cohen, Boerwinkle: "A weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levels." in: American journal of human genetics, Vol. 86, Issue 3, pp. 440-6, 2010 (PubMed).

Song, Washington, Crawford: "Loss of FOXA1/2 is essential for the epithelial-to-mesenchymal transition in pancreatic cancer." in: Cancer research, Vol. 70, Issue 5, pp. 2115-25, 2010 (PubMed).

Dayoub, Groitl, Dobner et al.: "Foxa2 (HNF-3beta) regulates expression of hepatotrophic factor ALR in liver cells." in: Biochemical and biophysical research communications, Vol. 395, Issue 4, pp. 465-70, 2010 (PubMed).