GSAP antibody (C-Term)

Catalog No. ABIN656412

The Rabbit Polyclonal anti-GSAP antibody (Clone RB27384) (ABIN656412) specifically detects GSAP in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for GSAP antibody (C-Term) (ABIN656412)

Target: GSAP (PION) (Pigeon Homolog (PION))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GSAP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB27384

Product Details anti-GSAP Antibody

Binding Specificity: AA 537-565, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PION antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 537-565 amino acids from the C-terminal region of human PION.

Isotype: IgG

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: PION Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

Target Details for GSAP

Target: GSAP (PION) (Pigeon Homolog (PION))

Alternative Name: PION

Background: Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD, MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1, MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP, MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).

Molecular Weight: 97802

Gene ID: 54103

NCBI Accession: NP_059135

UniProt: A4D1B5