|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Iron-Responsive Element Binding Protein 2 (IREB2) (Center) antibody
|Synonyms||ACO3, IRP2, IRP2AD, FLJ23381, IREB2, im:7153062, DKFZp468N047|
Alternatives Western Blotting (WB), ELISA
|5 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This IREB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-238 amino acids from the Central region of human IREB2.|
|Description||Other names: Iron-responsive element-binding protein 2,IREB2,|
|Characteristics||Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This IREB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-238 amino acids from the Central region of human IREB2.|
|Molecular Weight||105045 DA|
Background: IREB2 is a RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||IREB2 Antibody (Center) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.|
|Research Area||Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Chromatin, Signaling, Cell Structure|
|Restrictions||For Research Use only|
Salahudeen, Thompson, Ruiz et al.: "An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis." in: Science (New York, N.Y.), Vol. 326, Issue 5953, pp. 722-6, 2009 (PubMed).
DeMeo, Mariani, Bhattacharya et al.: "Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene." in: American journal of human genetics, Vol. 85, Issue 4, pp. 493-502, 2009 (PubMed).
Cho, Boutaoui, Klanderman et al.: "Variants in FAM13A are associated with chronic obstructive pulmonary disease." in: Nature genetics, Vol. 42, Issue 3, pp. 200-2, 2010 (PubMed).
Hansen, Xiao, Rice et al.: "Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans." in: Human molecular genetics, Vol. 19, Issue 18, pp. 3652-61, 2010 (PubMed).
Ucisik-Akkaya, Davis, Do et al.: "Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection." in: Molecular human reproduction, Vol. 16, Issue 10, pp. 770-7, 2010 (PubMed).
|Hosts||Rabbit (10), Goat (3), Mouse (1)|
|Reactivities||Human (8), Mouse (Murine) (5), Rat (Rattus) (4), Dog (Canine) (1), Pig (Porcine) (1), Xenopus laevis (1)|
|Applications||Western Blotting (WB) (14), ELISA (8), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (3), Flow Cytometry (FACS) (1)|
|Epitopes||Internal Region (3), N-Term (3)|