Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2) (N-Term) antibody

Antigen: Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2)

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN656896

Additional Information

Alternative name: MBTPS2

Gene ID: 51360

UniProt: NP_056968.1, O43462

Immunogen: This MBTPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-44 amino acids from the N-terminal region of human MBTPS2.

Isotype: Ig

Description: Other names: Membrane-bound transcription factor site-2 protease,MBTPS2,S2P

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This MBTPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-44 amino acids from the N-terminal region of human MBTPS2.

Molecular Weight: 57444 DA

Comments:

Background: This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome), IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: MBTPS2 Antibody (N-term) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.

Research Area: Protein Modifications, Cell Structure, Metabolism

Restrictions: For Research Use only

Images

MBTPS2 Antibody (N-term) (ABIN656896) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MBTPS2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Publications

Product: Lee, Tirasophon, Shen et al.: "IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response." in: Genes & development, Vol. 16, Issue 4, pp. 452-66, 2002 (PubMed).