FGD4 antibody (N-Term)

Catalog No. ABIN656907

The Rabbit Polyclonal anti-FGD4 antibody (Clone RB32509) (ABIN656907) specifically detects FGD4 in WB. The antibody is reactive with Human samples.

Quick Overview for FGD4 antibody (N-Term) (ABIN656907)

Target: FGD4 (FYVE, RhoGEF and PH Domain Containing 4 (FGD4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGD4 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB32509

Product Details anti-FGD4 Antibody

Binding Specificity: AA 157-186, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This FGD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 157-186 amino acids from the N-terminal region of human FGD4.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: FGD4 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

Target Details for FGD4

Target: FGD4 (FYVE, RhoGEF and PH Domain Containing 4 (FGD4))

Alternative Name: FGD4

Background: This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. [provided by RefSeq].

Molecular Weight: 86626

Gene ID: 121512

NCBI Accession: NP_640334

UniProt: Q96M96

Pathways: Neurotrophin Signaling Pathway