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Histone Cluster 1, H2ab (HIST1H2AB) (N-Term) antibody
Western Blotting (WB), ELISA
|3 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Gene ID||8335, 3012|
|UniProt||P04908, NP_066390.1, NP_003504.2|
|Immunogen||This HIST1H2AB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-40 amino acids from the N-terminal region of human HIST1H2AB.|
|Description||Other names: Histone H2A type 1-B/E,HIST1H2AB,H2AFM|
|Characteristics||Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This HIST1H2AB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-40 amino acids from the N-terminal region of human HIST1H2AB.|
|Molecular Weight||14135 DA|
Background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails, instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||HIST1H2AB Antibody (N-term) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.|
|Research Area||Ubiquitin-related antibodies, Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Cell Structure|
|Restrictions||For Research Use only|
Andersen, Lam, Leung et al.: "Nucleolar proteome dynamics." in: Nature, Vol. 433, Issue 7021, pp. 77-83, 2005 (PubMed).
Hagiwara, Hidaka, Yamada: "Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes." in: Biochemistry, Vol. 44, Issue 15, pp. 5827-34, 2005 (PubMed).
Cao, Tsukada, Zhang: "Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing." in: Molecular cell, Vol. 20, Issue 6, pp. 845-54, 2005 (PubMed).