WD Repeat Domain 12 (WDR12) (Center) antibody

Antigen: WD Repeat Domain 12 (WDR12)

Synonyms: YTM1, FLJ10881, FLJ12719, FLJ12720, Ytm1, Ytm1p, 4933402C23Rik, fb24f09, zgc:55609, wu:fb24f09, WDR12, DKFZp459M1426

Binding Site: Center

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN657000

Additional Information

Alternative name: WDR12

Gene ID: 55759

UniProt: Q9GZL7, NP_060726.3

Immunogen: This WDR12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 209-239 amino acids from the Central region of human WDR12.

Isotype: Ig

Description: Other names: Ribosome biogenesis protein WDR12,WDR12,

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This WDR12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 209-239 amino acids from the Central region of human WDR12.

Molecular Weight: 47708 DA

Comments:

Background: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: WDR12 Antibody (Center) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.

Research Area: Signaling, Protein Modifications, Transcription Factors, Cell Structure

Restrictions: For Research Use only

Publications

Product: Hölzel, Rohrmoser, Schlee et al.: "Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation." in: The Journal of cell biology, Vol. 170, Issue 3, pp. 367-78, 2005 (PubMed).

Grimm, Hölzel, Rohrmoser et al.: "Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex." in: Nucleic acids research, Vol. 34, Issue 10, pp. 3030-43, 2006 (PubMed).

, Kathiresan, Voight et al.: "Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants." in: Nature genetics, Vol. 41, Issue 3, pp. 334-41, 2009 (PubMed).