WD Repeat Domain 45 (WDR45) (N-Term) antibody

Antigen: WD Repeat Domain 45 (WDR45)

Synonyms: JM5, WDRX1, WIPI4, WIPI-4, Sfc19, Wdrx1, C79260, DXImx38e, MGC56345, zgc:56345, zgc:77017, MGC80694, MGC139750

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN657236

Additional Information

Alternative name: WDR45

Isotype: Ig

Description: Other names: WD repeat domain phosphoinositide-interacting protein 4,WDR45,WDRX1, WDRXI4, WIPI4

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This WDR45 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of human WDR45.

Comments:

Background: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined.

Application Details

Concentration: 0.25 mg/ml

Purification: Purified

Research Area: Cell Structure

Restrictions: For Research Use only

Images

WDR45 Antibody (N-term) (ABIN657236) western blot analysis in A549 cell line lysates (35ug/lane). This demonstrates the WDR45 antibody detected the WDR45 protein (arrow).

Publications

Product: Clark, Glanowski, Nielsen et al.: "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios." in: Science (New York, N.Y.), Vol. 302, Issue 5652, pp. 1960-3, 2003 (PubMed).

Jeffries, Dove, Michell et al.: "PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49." in: Molecular biology of the cell, Vol. 15, Issue 6, pp. 2652-63, 2004 (PubMed).

Proikas-Cezanne, Waddell, Gaugel et al.: "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy." in: Oncogene, Vol. 23, Issue 58, pp. 9314-25, 2004 (PubMed).