|+1 404 474 4654|
|+1 888 205 9894 (TF)|
PHD Finger Protein 17 (PHF17) (N-Term) antibody
|Synonyms||JADE1, FLJ22479, KIAA1807, Jade1, AU041499, mKIAA1807, D530048A03Rik|
Alternatives Western Blotting (WB), ELISA
|5 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|UniProt||NP_079176.2, Q6IE81, NP_955352.1|
|Immunogen||This PHF17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-51 amino acids from the N-terminal region of human PHF17.|
|Description||Other names: Protein Jade-1,PHF17,JADE1, KIAA1807|
|Characteristics||Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This PHF17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-51 amino acids from the N-terminal region of human PHF17.|
|Molecular Weight||95533 DA|
Background: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor.
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||PHF17 Antibody (N-term) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.|
|Research Area||Apoptosis/Necrosis, Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Signaling, Cell Structure|
|Restrictions||For Research Use only|
|PHF17 Antibody (N-term) (ABIN657355) western blot analysis in mouse heart tissue lysates (35ug/lane). This demonstrates the PHF17 antibody detected the PHF17 protein (arrow).|
Doyon, Cayrou, Ullah et al.: "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation." in: Molecular cell, Vol. 21, Issue 1, pp. 51-64, 2006 (PubMed).
Lim, Hao, Shaw et al.: "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration." in: Cell, Vol. 125, Issue 4, pp. 801-14, 2006 (PubMed).
Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).
Foy, Song, Chitalia et al.: "Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex." in: The Journal of biological chemistry, Vol. 283, Issue 43, pp. 28817-26, 2008 (PubMed).
Chitalia, Foy, Bachschmid et al.: "Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL." in: Nature cell biology, Vol. 10, Issue 10, pp. 1208-16, 2008 (PubMed).
|Reactivities||Human (12), Mouse (Murine) (8), Rat (Rattus) (8), Chicken (4), Cow (Bovine) (4), Dog (Canine) (2), Xenopus laevis (2), Zebrafish (2), Cat (Feline) (1)|
|Applications||Western Blotting (WB) (12), ELISA (7), Immunohistochemistry (IHC) (2), Immunofluorescence (IF) (1), Immunoprecipitation (IP) (1)|
|Epitopes||C-Term (2), Internal Region (1), N-Term (1)|