Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A) (C-Term) antibody

Antigen: Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A)

Synonyms: CD32, FCG2, FcGR, CD32A, CDw32, FCGR2, IGFR2, FCGR2A1, MGC23887, MGC30032

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN657646

Additional Information

Alternative name: FCGR2A

Gene ID: 2212

UniProt: NP_001129691.1, P12318, NP_067674.2

Immunogen: This FCGR2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-285 amino acids from the C-terminal region of human FCGR2A.

Isotype: Ig

Description: Other names: Low affinity immunoglobulin gamma Fc region receptor II-a,FCGR2A,CD32, FCG2, FCGR2A1, IGFR2

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This FCGR2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-285 amino acids from the C-terminal region of human FCGR2A.

Molecular Weight: 35001 DA

Comments:

Background: This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: FCGR2A Antibody (C-term) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.

Research Area: Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications

Restrictions: For Research Use only

Publications

Product: Dornan, Spleiss, Yeh et al.: "Effect of FCGR2A and FCGR3A variants on CLL outcome." in: Blood, Vol. 116, Issue 20, pp. 4212-22, 2010 (PubMed).

Zhang, Booth: "Divergent intracellular sorting of Fc{gamma}RIIA and Fc{gamma}RIIB2." in: The Journal of biological chemistry, Vol. 285, Issue 44, pp. 34250-8, 2010 (PubMed).