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C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (Center) antibody

Antigen

C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1)
Synonyms ABL, JTK7, p150, c-ABL, v-abl, bcr/abl, Abl, c-Abl, AI325092, MGC117749, E430008G22Rik, ABL1, ARG, ABLL, FLJ22224, FLJ31718, FLJ41441, Arg, Abll, AA536808, MGC169395, ABL2, CABL, cb272
Binding Site
Alternatives

Center
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Mouse (Murine)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), ELISA
2 references available
Certificates ISO 9001:2008
Catalog no. ABIN657828
Quantity 0.1 mg  (0.25 mg/ml)  (Variants)
Price 280.50 $   Plus shipping costs $45.00
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anti-C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (Center) antibody

Additional Information
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Alternative name Abl1
Gene ID 11350
UniProt NP_033724.2, P00520, NP_001106174.1
Immunogen This Mouse Abl1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 612-642 amino acids from the Central region of human Mouse Abl1.
Isotype Ig
Description Other names: Tyrosine-protein kinase ABL1,Abl1,Abl
Characteristics Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Specificity This Mouse Abl1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 612-642 amino acids from the Central region of human Mouse Abl1.
Molecular Weight 122673 DA
Comments

Background: Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.

Application Details
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Application Notes The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500
Concentration 0.25 mg/ml
Purification Purified
Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage Mouse Abl1 Antibody (Center) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.
Research Area Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Cancer, Chromatin, Signaling
Restrictions For Research Use only

Publications
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Product Perez de Arce, de Arce, Varela-Nallar et al.: "Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 10, pp. 3728-38, 2010 (PubMed).

Ko, Lee, Shin et al.: "Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 38, pp. 16691-6, 2010 (PubMed).

Alternatives
Application Details Publications Images Variants back to top

Alternatives for antigen "C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1)", type "Antibodies"
Hosts Rabbit (193), Mouse (17)
Reactivities Human (208), Mouse (Murine) (123), Rat (Rattus) (111), Cow (Bovine) (64), Dog (Canine) (58), Horse (Equine) (58), Pig (Porcine) (58), Guinea Pig (23), Chicken (18), Monkey (2)
Applications Western Blotting (WB) (102), Immunofluorescence (IF) (90), ELISA (84), Immunohistochemistry (IHC) (46), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (43), Immunoprecipitation (IP) (17), Dot Blot (Dot) (7), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (6), Immunocytochemistry (ICC) (5), Immunoelectron Microscopy (IEM) (2), Dot Blot (DB) (1), Flow Cytometry (FACS) (1), Immunodiffusion (ID) (1)
Conjugates Alexa Fluor 350 (11), Alexa Fluor 488 (11), Alexa Fluor 555 (11), Alexa Fluor 647 (11), PE,Cy5.5 (10), Biotin (6), FITC (3), HRP (3), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), Gold (2), PE (2), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1), Un-conjugated (1)
Epitopes pTyr412 (16), Tyr70 (12), pTyr204 (12), pTyr245 (11), pThr754 (7), pTyr251 (7), pTyr272 (7), pTyr276 (6), pTyr283 (6), pTyr70 (6), C-Term (5), pTyr89 (5), N-Term (4), SH2 Domain (3), AA 577-650 (2), Internal Region (2), pThr735 (2), pTyr134 (2), AA 929-1020 (1), Center (1), N-Term,His246 (1), N-Term,Lys219 (1), Thr735 (1), Tyr251 (1), pSer112 (1), pSer83 (1), pThr309,pThr308 (1), pThr845 (1), pTyr223 (1), pTyr393 (1)