|+1 404 474 4654|
|+1 888 205 9894 (TF)|
C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (Center) antibody
|Synonyms||ABL, JTK7, p150, c-ABL, v-abl, bcr/abl, Abl, c-Abl, AI325092, MGC117749, E430008G22Rik, ABL1, ARG, ABLL, FLJ22224, FLJ31718, FLJ41441, Arg, Abll, AA536808, MGC169395, ABL2, CABL, cb272|
Alternatives Western Blotting (WB), ELISA
|2 references available|
|Quantity||0.1 mg (0.25 mg/ml) (Variants)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|UniProt||NP_033724.2, P00520, NP_001106174.1|
|Immunogen||This Mouse Abl1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 612-642 amino acids from the Central region of human Mouse Abl1.|
|Description||Other names: Tyrosine-protein kinase ABL1,Abl1,Abl|
|Characteristics||Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This Mouse Abl1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 612-642 amino acids from the Central region of human Mouse Abl1.|
|Molecular Weight||122673 DA|
Background: Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Mouse Abl1 Antibody (Center) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.|
|Research Area||Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Cancer, Chromatin, Signaling|
|Restrictions||For Research Use only|
|Mouse Abl1 Antibody (Center) (ABIN657828) western blot analysis in mouse spleen tissue lysates (35ug/lane). This demonstrates the Abl1 antibody detected the Abl1 protein (arrow).|
Perez de Arce, de Arce, Varela-Nallar et al.: "Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 10, pp. 3728-38, 2010 (PubMed).
Ko, Lee, Shin et al.: "Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 38, pp. 16691-6, 2010 (PubMed).