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Transforming Growth Factor, beta 2 (TGFB2) antibody

Details for Product No. ABIN659106
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Antigen
Synonyms TGFB2, LDS4, TGF-beta2, BB105277, Tgf-beta2, Tgfb-2, TGF-B2, MGF, TGFbeta2, tgf-beta2, tgfb2-A, TGF-beta 2, Tgfbr2T
Reactivity
Human
(99), (47), (46), (13), (13), (13), (12), (6), (1)
Host
Mouse
(96), (14), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Immunofluorescence (IF), Western Blotting (WB)
(62), (42), (33), (26), (20), (11), (6), (3), (2), (2), (1), (1)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN659106
291.50 $
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Immunogen This TGFB2 monoclonal antibody is generated from mouse immunized with TGFB2 recombinant protein.
Clone 220ct16-4-3-1
Isotype IgG1, kappa
Specificity This TGFB2 monoclonal antibody is generated from mouse immunized with TGFB2 recombinant protein.
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name TGFB2
Background This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1,7)(q41,p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms: Transforming growth factor beta-2,TGFB2,
Pathways: Hypertrophic cardiomyopathy (HCM), Cytokine-cytokine receptor interaction, MAPK signaling pathway, Toxoplasmosis, Pathways in cancer, Tuberculosis, Malaria, Dilated cardiomyopathy, Endocytosis, Rheumatoid arthritis, Cell cycle, Leishmaniasis, Renal cell carcinoma, Chagas disease (American trypanosomiasis), Colorectal cancer, Pancreatic cancer, TGF-beta signaling pathway, Osteoclast differentiation, Chronic myeloid leukemia, Amoebiasis
Molecular Weight 47748 Da
Gene ID 7042
UniProt P61812
Research Area Cell Signaling, Protein Modifications, Cell Cycle, Chromatin, Signaling, Cell Structure
Application Notes IHC = 1:10-50, IF = 1:10-50, WB = 1:100-1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Transforming Growth Factor, beta 2 (TGFB2) antibody TGFB2 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TGFB2 Antibody for immunohistochemistry. Clinical relevance has not been evaluated.
anti-Transforming Growth Factor, beta 2 (TGFB2) antibody (2) TGFB2 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TGFB2 Antibody for immunohistochemistry. Clinical relevance has not been evaluated.
anti-Transforming Growth Factor, beta 2 (TGFB2) antibody (3) Confocal immunofluorescent analysis of TGFB2 Antibody with A549 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).
anti-Transforming Growth Factor, beta 2 (TGFB2) antibody (4) TGFB2/MB10181 antibody western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the TGFB2/MB10181 antibody detected the TGFB2/MB10181 protein (arrow).
Background publications Sambo, Trovoada, Benchimol et al.: "Transforming growth factor beta 2 and heme oxygenase 1 genes are risk factors for the cerebral malaria syndrome in Angolan children." in: PLoS ONE, Vol. 5, Issue 6, pp. e11141, 2010 (PubMed).

Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).

Validation Images
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