TRAF2 antibody

Catalog No. ABIN659110

This Mouse Monoclonal antibody specifically detects TRAF2 in WB and IF. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for TRAF2 antibody (ABIN659110)

Target: TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TRAF2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 214CT16-3-4

Product Details anti-TRAF2 Antibody

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This TRAF2 monoclonal antibody is generated from mouse immunized with TRAF2 recombinant protein.

Isotype: IgG1 kappa

Application Details

Application Notes: IF: 1:10~50. WB: 1:1000. WB: 1:100~1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-TRAF2 antibody (ABIN659110)

Akhtar, Singh, Ahmed: "MicroRNA-17 Suppresses TNF-α Signaling by Interfering with TRAF2 and cIAP2 Association in Rheumatoid Arthritis Synovial Fibroblasts." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 197, Issue 6, pp. 2219-28, (2017) (PubMed).

Target Details for TRAF2

Target: TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))

Alternative Name: TRAF2

Background: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.

Molecular Weight: 55859

Gene ID: 7186

NCBI Accession: NP_066961

UniProt: Q12933

Pathways: NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response, S100 Proteins