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TRAF2 antibody (TNF Receptor-Associated Factor 2)

Details for Product anti-TRAF2 Antibody No. ABIN659110, Supplier: Log in to see
Antigen
  • MGC:45012
  • TRAP
  • TRAP3
  • TANK
  • AI325259
Alternatives
anti-Human TRAF2 antibody for Western Blotting
Reactivity
Human
152
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43
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2
1
1
Host
Mouse
101
38
18
1
Clonality (Clone)
Monoclonal ()
Conjugate
This TRAF2 antibody is un-conjugated
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6
5
4
4
4
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
136
70
54
25
19
19
11
8
5
5
3
2
Supplier
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Immunogen This TRAF2 monoclonal antibody is generated from mouse immunized with TRAF2 recombinant protein.
Clone 214CT16-3-4
Isotype IgG1, kappa
Specificity This TRAF2 monoclonal antibody is generated from mouse immunized with TRAF2 recombinant protein.
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name TRAF2 (TRAF2 Antibody Abstract)
Background The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.
Synonyms: TNF receptor-associated factor 2,TRAF2,TRAP3
Pathways: Hepatitis C, Adipocytokine signaling pathway, MAPK signaling pathway, Pathways in cancer, RIG-I-like receptor signaling pathway, Protein processing in endoplasmic reticulum, Small cell lung cancer, Apoptosis, Osteoclast differentiation
Molecular Weight 55859 Da
Gene ID 7186
UniProt Q12933
Research Area Ubiquitin-related antibodies, Apoptosis/Necrosis, Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure
Pathways NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis
Application Notes IF = 1:10-50, WB = 1:100-1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Immunofluorescence (IF) image for anti-TRAF2 antibody (TNF Receptor-Associated Factor 2) (ABIN659110) Confocal immunofluorescent analysis of TRAF2 Antibody with MCF-7 cell followed by Al...
Western Blotting (WB) image for anti-TRAF2 antibody (TNF Receptor-Associated Factor 2) (ABIN659110) TRAF2/MB10188 antibody western blot analysis in T47D cell line lysates (35ug/lane).T...
Background publications Alvarez, Harikumar, Hait et al.: "Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2." in: Nature, Vol. 465, Issue 7301, pp. 1084-8, 2010 (PubMed).