SLC22A8 antibody (AA 31-110)

Catalog No. ABIN670821

Cited in 3+ publications. The Rabbit Polyclonal anti-SLC22A8 antibody (ABIN670821) specifically detects SLC22A8 in WB, ELISA and IHC (p). The antibody is reactive with Mouse and Rat samples.

Quick Overview for SLC22A8 antibody (AA 31-110) (ABIN670821)

Target: SLC22A8 (Solute Carrier Family 22 (Organic Anion Transporter), Member 8 (SLC22A8))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC22A8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SLC22A8 Antibody

Binding Specificity: AA 31-110

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human OAT-3

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-SLC22A8 antibody (ABIN670821)

Zhu, Dong, Na, Han, Wei, Chen: "Saponins extracted from Dioscorea collettii rhizomes regulate the expression of urate transporters in chronic hyperuricemia rats." in: Biomedicine & pharmacotherapy, Vol. 93, pp. 88-94, (2017) (PubMed).

Enoki, Watanabe, Arake, Sugimoto, Imafuku, Tominaga, Ishima, Kotani, Nakajima, Tanaka, Matsushita, Fukagawa, Otagiri, Maruyama: "Indoxyl sulfate potentiates skeletal muscle atrophy by inducing the oxidative stress-mediated expression of myostatin and atrogin-1." in: Scientific reports, Vol. 6, pp. 32084, (2016) (PubMed).

Zhou, Yu, Zhang, Liu, Lu: "Total saponins from Discorea nipponica ameliorate urate excretion in hyperuricemic mice." in: Planta medica, Vol. 80, Issue 15, pp. 1259-68, (2014) (PubMed).

Target Details for SLC22A8

Target: SLC22A8 (Solute Carrier Family 22 (Organic Anion Transporter), Member 8 (SLC22A8))

Alternative Name: OAT-3

Background:

Synonyms: OAT3, Solute carrier family 22 member 8, Organic anion transporter 3, hOAT3, SLC22A8

Background: Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).

Gene ID: 9376

UniProt: Q8TCC7