Vdcc-L alpha (AA 1001-1100) antibody

Catalog No. ABIN680983

This Rabbit Polyclonal antibody specifically detects Vdcc-L alpha in IF (p), IF (cc), ELISA, IHC (fro) and IHC (p). It exhibits reactivity toward Mouse and Rat.It has been mentioned in 1 publication

Quick Overview for Vdcc-L alpha (AA 1001-1100) antibody (ABIN680983)

Target: Vdcc-L alpha

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details

Binding Specificity: AA 1001-1100

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human VDCC-L alpha

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References

Lobeck, Donnelly, Dupree, Mahe, McNeal, Mohanty, Tiao: "Rhesus rotavirus VP6 regulates ERK-dependent calcium influx in cholangiocytes." in: Virology, Vol. 499, pp. 185-195, (2016) (PubMed).

Target Details

Target: Vdcc-L alpha

Background:

Synonyms: VDCC-L alpha 1, L-VDCC alpha 1, Voltage dependent calcium channel subunit alpha 1, CACNL1A1, Alpha1c L-type VDCC, CACBR, CACH2, CACN2, CACNA1C, CACNL1A1, CaV1.2, CCHL1A1, L-TYPE CALCIUM CHANNEL ALPHA1C, L-type voltage dependent calcium channel a1, L-TYPE VOLTAGE DEPENDENT CALCIUM CHANNEL ALPHA 1.2, L-VDCC ALPHA1, LOC283439, MGC120730, RATIVS302, TS, CAC1C_HUMAN.

Background: This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. [provided by RefSeq]

Gene ID: 775